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首页> 外文期刊>Infection and immunity >Adoptively transferred anti-idiotype pulsed B cells mediate autoimmune myocarditis.
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Adoptively transferred anti-idiotype pulsed B cells mediate autoimmune myocarditis.

机译：过继转移的抗独特型脉冲B细胞介导自身免疫性心肌炎。

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摘要

Syngeneic mice receiving adoptively transferred enriched B cells or splenocytes pulsed in vitro with polyclonal anti-idiotypic antibodies (anti-Ids) against anti-CVB3 virus antibodies developed coxsackievirus B3 antigen-binding and virus-neutralizing antibodies during a 30-day period, in addition to overt expression of autoimmune myocarditis. Adoptive transfer of anti-Id pulsed T cells resulted in delayed appearance and transient expression of antiviral antibodies, and antiviral antibodies were marginal to absent in syngeneic animals receiving anti-Id pulsed macrophage populations. Proliferation analysis of recipient splenocytes indicated lack of proliferative capacity in response to monoclonal or polyclonal anti-Ids and only marginal proliferative capacity in response to coxsackievirus B3 virus antigen(s). In vitro assessment of delayed hypersensitivity in recipient animals demonstrated some specific immunity to anti-Ids in recipients receiving splenocytes or T cells. Anti-Ids expressing mimicry for heart-associated and/or viral antigen(s) interacting with B cells or other accessory cells suggest an autoantibody or anti-Id triggering of B-cell-mediated mechanisms involved in the development of myocarditis.
机译：接受过继转移转移的富集B细胞或脾细胞的体外抗CVB3病毒多克隆抗独特型抗体（anti-Ids）的同系小鼠在30天的时间内开发了柯萨奇B3抗原结合抗体和病毒中和抗体公开表达自身免疫性心肌炎。抗Id脉冲T细胞的过继转移导致抗病毒抗体的出现和瞬时表达的延迟，并且抗病毒抗体在接受抗Id脉冲巨噬细胞群体的同系动物中几乎没有。受体脾细胞的增殖分析表明缺乏对单克隆或多克隆抗-Ids应答的增殖能力，而仅对边际柯萨奇病毒B3病毒抗原应答的边缘增殖能力。受体动物迟发型超敏反应的体外评估表明，在接受脾细胞或T细胞的受体中，抗-Ids具有特定的免疫力。表达模仿与B细胞或其他辅助细胞相互作用的心脏相关和/或病毒抗原的抗Ids，提示自身抗体或抗Id触发B细胞介导的心肌炎发展机制。

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