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首页> 外文期刊>Infection and immunity >T-cell, adhesion, and B-cell epitopes of the cell surface Streptococcus mutans protein antigen I/II.
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T-cell, adhesion, and B-cell epitopes of the cell surface Streptococcus mutans protein antigen I/II.

机译：细胞表面变形链球菌蛋白抗原I / II的T细胞，粘附和B细胞表位。

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The T-cell and antibody responses to a cell surface streptococcal antigen (SA I/II) were investigated in naturally sensitized humans. Serum antibody responses were directed predominantly to the N-terminal (residues 39 to 481) and central (residues 816 to 1213) regions of SA I/II which may be involved in bacterial adhesion to salivary receptors. T-cell responses were also directed predominantly towards the central region. The linear peptide relationship of the immunodominant and minor T- and B-cell as well as adhesion epitopes was mapped within residues 816 to 1213. Immunodominant T-cell and B-cell epitopes were identified within residues 803 to 853, which were separated in linear sequence from the adhesion epitopes (residues 1005 to 1044). Adhesion epitopes overlapped with minor B- and T-cell epitopes (residues 1005 to 1054 and 1085 to 1134). An immunodominant promiscuous T-cell epitope (residues 985 to 1004) was adjacent to an adhesion epitope (residues 1005 to 1024). The limited B-cell response to adhesion epitopes is consistent with the success of Streptococcus mutans in colonizing the oral cavity. The strategy of T-cell, adhesion, and B-cell epitope mapping has revealed a general approach for identifying components of subunit vaccines which may focus responses to critical functional determinants. Such epitopes of SA I/II may constitute the components of a subunit vaccine against dental caries.
机译：在自然致敏的人类中研究了T细胞和抗体对细胞表面链球菌抗原（SA I / II）的反应。血清抗体应答主要针对SA I / II的N末端（39至481位残基）和中央（816至1213位残基）区域，这些区域可能与细菌与唾液受体的粘附有关。 T细胞反应也主要针对中部地区。免疫显性和次要T细胞和B细胞以及粘附表位的线性肽关系被定位在残基816至1213内。免疫原性T细胞和B细胞表位在残基803至853中被鉴定，并以线性方式分离粘附表位的序列（残基1005至1044）。粘附表位与次要B细胞和T细胞表位重叠（残基1005至1054和1085至1134）。免疫显性的混杂T细胞表位（985至1004残基）与粘附表位（1005至1024残基）相邻。对粘附表位的有限的B细胞反应与变形链球菌在口腔中的成功形成一致。 T细胞，粘附和B细胞表位作图的策略揭示了一种通用的方法，可用于鉴定亚单位疫苗的成分，这些成分可能集中于对关键功能决定簇的反应。 SA I / II的此类表位可以构成针对龋齿的亚单位疫苗的成分。

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