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E and P Selectins Are Not Required for Resistance to Severe Murine Lyme Arthritis

机译:E和P选择素对重症鼠莱姆关节炎没有抵抗力

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Borrelia burgdorferi-induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils to sites of inflammation, mice with this deficiency were tested for their response to infection with B. burgdorferi. E and P selectins were not required for the control of B. burgdorferi numbers, nor did deficiency in E and P selectins result in alteration of arthritis severity.
机译: Borrelia burgdorferi 诱发的小鼠关节炎的特征是肌腱炎,滑膜炎和炎性细胞浸润,主要是中性粒细胞浸润。由于E和P选择素的遗传缺陷导致嗜中性粒细胞延迟募集到炎症部位,因此测试了这种缺陷小鼠对 B感染的反应。 burgdorferi 。 E和P选择素不需要控制 B。 burgdorferi 的数量,E和P选择素的缺乏也不会导致关节炎严重程度的改变。

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