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首页> 外文期刊>Infection and immunity >Role of Gamma Interferon in Cellular Immune Response against Murine Encephalitozoon cuniculiInfection
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Role of Gamma Interferon in Cellular Immune Response against Murine Encephalitozoon cuniculiInfection

机译：γ干扰素在针对小鼠脑炎性感染的细胞免疫反应中的作用

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摘要

Microsporidia are obligate intracellular protozoan parasites that cause a wide variety of opportunistic infection in patients with AIDS. Because it is able to grow in vitro, Encephalitozoon cuniculi is currently the best-studied microsporidian. T cells mediate protective immunity against this parasite. Splenocytes obtained from infected mice proliferate in vitro in response to irradiated parasites. A transient state of hyporesponsiveness to parasite antigen and mitogen was observed at day 17 postinfection. This downregulatory response could be partially reversed by addition of nitric oxide (NO) antagonist to the culture. Mice infected withE. cuniculi secrete significant levels of gamma interferon (IFN-γ). Treatment with antibody to IFN-γ or interleukin-2 (IL-12) was able to neutralize the resistance to the parasite. Mutant animals lacking the IFN-γ or IL-12 gene were highly susceptible to infection. However, mice unable to secrete NO withstood high doses of parasite challenge, similar to normal wild-type animals. These studies describe an IFN-γ-mediated protection against E. cuniculi infection that is independent of NO production.
机译：小孢子虫病是专性的细胞内原生动物寄生虫，可在艾滋病患者中引起多种机会性感染。由于它可以在体外生长，因此 cucephaluli cuniculi 是目前研究最好的微孢子虫。 T细胞介导针对这种寄生虫的保护性免疫。从受感染的小鼠获得的脾细胞在体外对受辐照的寄生虫增殖。感染后第17天观察到对寄生虫抗原和有丝分裂原的低反应性的短暂状态。通过向培养物中添加一氧化氮（NO）拮抗剂，可以部分逆转这种下调反应。感染了 E的小鼠。 cuniculi 分泌大量的γ-干扰素（IFN-γ）。用抗IFN-γ或白介素2（IL-12）抗体处理能够中和对寄生虫的抗性。缺少IFN-γ或IL-12基因的突变动物极易感染。但是，与正常野生型动物相似，无法分泌NO的小鼠经受了高剂量的寄生虫攻击。这些研究描述了IFN-γ介导的针对 E的保护。与NO产生无关的cuniculi 感染。

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