The CXC Chemokines Gamma Interferon (IFN-γ)-Inducible Protein 10 and Monokine Induced by IFN-γ Are Released during Severe Melioidosis

Fanny N. Lauw; Andrew J. H. Simpson; Jan M. Prins; Sander J. H. van Deventer; Wipada Chaowagul; Nicholas J. White; Tom van der Poll

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The CXC Chemokines Gamma Interferon (IFN-γ)-Inducible Protein 10 and Monokine Induced by IFN-γ Are Released during Severe Melioidosis

机译：CXC趋化因子γ干扰素（IFN-γ）诱导蛋白10和IFN-γ诱导的单核因子在严重的类胡萝卜素病期间释放

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Gamma interferon (IFN-γ)-inducible protein 10 (IP-10) and monokine induced by IFN-γ (Mig) are related CXC chemokines which bind to the CXCR3 receptor and specifically target activated T lymphocytes and natural killer (NK) cells. The production of IP-10 and Mig by various cell types in vitro is strongly dependent on IFN-γ. To determine whether IP-10 and Mig are released during bacterial infection in humans, we measured plasma levels of IP-10 and Mig in patients with melioidosis, a severe gram-negative infection caused byBurkholderia pseudomallei. IP-10 and Mig were markedly elevated in patients with melioidosis on admission, particularly in blood culture-positive patients, and remained elevated during the 72-h study period. Levels of IP-10 and Mig showed a positive correlation with IFN-γ concentrations and also correlated with clinical outcome. In whole blood stimulated with heat-killed B. pseudomallei, neutralization of IFN-γ and tumor necrosis factor alpha (TNF-α) partly attenuated IP-10 and Mig release, while anti-interleukin-12 (IL-12) and anti-IL-18 had a synergistic effect. Stimulation with other bacteria or endotoxin also induced strong secretion of IP-10 and Mig. These data suggest that IP-10 and Mig are part of the innate immune response to bacterial infection. IP-10 and Mig may contribute to host defense in Th1-mediated host defense during infections by attracting CXCR3+ Th1 cells to the site of inflammation.

机译：γ-干扰素（IFN-γ）诱导蛋白10（IP-10）和由IFN-γ（Mig）诱导的单因子是相关的CXC趋化因子，它们与CXCR3受体结合，并特别靶向活化的T淋巴细胞和自然杀伤（NK）细胞。各种细胞类型在体外产生IP-10和Mig的过程强烈依赖于IFN-γ。为了确定在人类细菌感染过程中IP-10和Mig是否释放，我们测量了类拟鼻osis病患者的血浆IP-10和Mig的水平，类拟南芥是由假阳性伯克霍尔德氏菌引起的严重革兰氏阴性感染。 IP-10和Mig在入院的类胡osis病患者中明显升高，尤其是在血培养阳性患者中，并在72小时的研究期间保持升高。 IP-10和Mig的水平与IFN-γ浓度呈正相关，也与临床结果相关。用热杀死的 B刺激的全血。假性疟原虫，IFN-γ和肿瘤坏死因子α（TNF-α）的中和部分减弱了IP-10和Mig的释放，而抗白介素12（IL-12）和抗IL-18具有协同作用影响。用其他细菌或内毒素刺激也会诱导IP-10和Mig的强烈分泌。这些数据表明IP-10和Mig是对细菌感染的固有免疫反应的一部分。 IP-10和Mig通过将CXCR3 + Th1细胞吸引到炎症部位，可能在感染过程中有助于Th1介导的宿主防御。 展开▼

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《Infection and immunity》 |2000年第7期|共6页

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Fanny N. Lauw; Andrew J. H. Simpson; Jan M. Prins; Sander J. H. van Deventer; Wipada Chaowagul; Nicholas J. White; Tom van der Poll;
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1. The CXC Chemokines Gamma Interferon (IFN-γ)-Inducible Protein 10 and Monokine Induced by IFN-γ Are Released during Severe Melioidosis [J] . Fanny N. Lauw, Andrew J. H. Simpson, Jan M. Prins, Infection and immunity . 2000,第7期

机译：CXC趋化因子γ干扰素（IFN-γ）诱导蛋白10和IFN-γ诱导的单核因子在严重的类胡萝卜素病期间释放

2. Among CXCR3 Chemokines, IFN-γ-Inducible Protein of 10 kDa (CXC Chemokine Ligand (CXCL) 10) but Not Monokine Induced by IFN-γ (CXCL9) Imprints a Pattern for the Subsequent Development of Autoimmune Disease [J] . Urs Christen, Dorian B. McGavern, Andrew D. Luster, The journal of immunology . 2003,第12期

机译：在CXCR3趋化因子中，10 kDa的IFN-γ诱导蛋白（CXC趋化因子配体（CXCL）10）但不是由IFN-γ诱导的单因子（CXCL9）标记了自身免疫疾病随后发展的模式。

3. A Second Step of Chemotaxis After Transendothelial Migration: Keratinocytes Undergoing Apoptosis Release IFN-γ-Inducible Protein 10, Monokine Induced by IFN-γ, and IFN-γ-Inducible α-Chemoattractant for T Cell Chemotaxis Toward Epidermis in Atopic Dermatitis [J] . Sven Klunker, Axel Trautmann, Mübeccel Akdis, The journal of immunology . 2003,第2期

机译：内皮迁移后趋化性的第二步：角质形成细胞凋亡释放IFN-γ诱导蛋白10，IFN-γ诱导的单因子和IFN-γ诱导性α趋化性T细胞趋向于特应性皮炎的表皮趋化。

4. Liposomal lactoferrin induced significant increase of the interferon-alpha (IFN-α) producibility in healthy volunteers [C] . Atsushi Ishikado, Hiromichi Imanaka, Mayumi Kotani, International Conference on Food Factors . 2004

机译：脂质体乳铁蛋白诱导健康志愿者的干扰素-α（IFN-α）的显着增加

5. Validation of a cytometric bead-based immunoassay for tear interleukin 8 and interferon gamma inducible protein 10. [D] . Tran, My-Tho Karin. 2014

机译：验证了基于细胞计数珠的泪液白介素8和干扰素γ诱导蛋白10的免疫测定。

6. The CXC Chemokines Gamma Interferon (IFN-γ)-Inducible Protein 10 and Monokine Induced by IFN-γ Are Released during Severe Melioidosis [O] . Fanny N. Lauw, Andrew J. H. Simpson, Jan M. Prins, 2000

机译：CXC趋化因子γ干扰素（IFN-γ）诱导蛋白10和干扰素-γ诱导的单核因子在严重的类胡萝卜素病期间释放

7. The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis. [O] . Lauw, FN, Simpson, AJ, Prins, JM, 2000

机译：CXC趋化因子γ干扰素（IFN-γ）诱导蛋白10和IFN-γ诱导的单因子在严重类鼻li病期间释放。

1. 哮喘小鼠肺组织中趋化因子干扰素-γ诱导蛋白-10、干扰素-γ诱导单核细胞因子表达及其意义 [J] . 吴良霞 ,林晓亮 ,徐敏 . 蚌埠医学院学报 . 2009,第001期

2. 趋化因子γ-干扰素诱导蛋白-10、巨噬细胞炎性蛋白-1α、单核细胞趋化因子-1对结核性和恶性胸腔积液鉴别诊断的价值分析 [J] . 任兆强 ,王相海 ,林存智 . 中国医师进修杂志 . 2014,第025期

3. 干扰素诱导蛋白10及CXC趋化因子受体3在慢性乙型肝炎患者中的表达 [J] . 杨华 ,罗亚文 ,刘华庆 . 中华传染病杂志 . 2012,第006期

4. 哮喘小鼠肺组织中CXC趋化因子受体3和其配体干扰素-γ诱导蛋白-10的表达及意义 [J] . 吴良霞 ,吴珉 ,林晓亮 . 中华实用儿科临床杂志 . 2009,第016期

5. γ干扰素诱导单核因子和诱导蛋白10在婴儿巨细胞病毒肝炎相关性研究 [J] . 丁艳 ,贾德胜 ,王宝香 . 中国实用儿科杂志 . 2008,第007期

6. 抗HIV因子天花粉蛋白通过与趋化因子受体的相互作用增强趋化因子诱导的趋化作用和G蛋白的激活 [C] . 赵简 ,本立泓 ,吴亚兰 . 2000上海科技论坛综合报告会 . 2000

7. CD34造血祖细胞上CXC趋化因子受体3的表达及其配体γIP-10和Mig诱导的趋化性和粘附性研究 [A] . 王红艳 . 2001

1. 设计用于治疗人类疾病的干扰素诱导型蛋白－10(IP－10或CXCL10)趋化因子类似物 [P] . 中国专利： CN101200502A . 2008-06-18

2. 一种鸡干扰素IFN-λ与IFN-α的融合蛋白 [P] . 中国专利： CN106674354B . 2020.10.16

3. Interferon-gamma (IFN-) inducing factor (IGIF, IL-18) and peptide fragment thereof [P] . 外国专利： US6274709B1 . 2001-08-14

机译：干扰素-γ（IFN-）诱导因子（IGIF，IL-18）及其肽片段

4. DNA molecule encoding interferon-gamma (IFN-) inducing factor (IGIF, IL-18) and DNA fragment thereof [P] . 外国专利： US6277598B1 . 2001-08-21

机译：编码干扰素-γ诱导因子（IGIF，IL-18）的DNA分子及其DNA片段

5. Interferon-gamma (IFN-) inducing factor (IGIF, IL-18) purified from murine liver [P] . 外国专利： US5912324A . 1999-06-15

机译：从鼠肝中纯化的干扰素-γ（IFN-）诱导因子（IGIF，IL-18）

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The CXC Chemokines Gamma Interferon (IFN-γ)-Inducible Protein 10 and Monokine Induced by IFN-γ Are Released during Severe Melioidosis

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