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首页> 外文期刊>Infection and immunity >Coinfection with Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis Alters Murine Immune Responses, Pathogen Burden, and Severity of Lyme Arthritis
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Coinfection with Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis Alters Murine Immune Responses, Pathogen Burden, and Severity of Lyme Arthritis

机译：与伯氏疏螺旋体和人类粒细胞埃希氏病病原体的共感染改变了小鼠的免疫反应，病原体负担和莱姆关节炎的严重程度

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摘要

Lyme disease and human granulocytic ehrlichiosis (HGE) are tick-borne illnesses caused by Borrelia burgdorferi and the agent of HGE, respectively. We investigated the influence of dual infection with B. burgdorferi and the HGE agent on the course of murine Lyme arthritis and granulocytic ehrlichiosis. Coinfection resulted in increased levels of both pathogens and more severe Lyme arthritis compared with those in mice infected withB. burgdorferi alone. The increase in bacterial burden during dual infection was associated with enhanced acquisition of both organisms by larval ticks that were allowed to engorge upon infected mice. Coinfection also resulted in diminished interleukin-12 (IL-12), gamma interferon (IFN-γ), and tumor necrosis factor alpha levels and elevated IL-6 levels in murine sera. During dual infection, IFN-γ receptor expression on macrophages was also reduced, implying a decrease in phagocyte activation. These results suggest that coinfection of mice with B. burgdorferi and the HGE agent modulates host immune responses, resulting in increased bacterial burden, Lyme arthritis, and pathogen transmission to the vector.
机译：莱姆病和人类粒细胞埃希氏菌病（HGE）分别是由 Borrelia burgdorferi 和HGE的病原体引起的tick传播疾病。我们调查了 B双重感染的影响。 burgdorferi 和HGE试剂对鼠莱姆关节炎和粒细胞性埃希氏病的病程。与感染了emB的小鼠相比，共感染导致两种病原体水平升高和更严重的莱姆关节炎。 burgburgeri 。双重感染过程中细菌负担的增加与被tick虫感染的幼虫acquisition对两种生物的吸收增强有关。合并感染还导致鼠血清中白介素12（IL-12），γ干扰素（IFN-γ）和肿瘤坏死因子α水平降低以及IL-6水平升高。在双重感染过程中，巨噬细胞上的IFN-γ受体表达也降低了，这意味着吞噬细胞的激活减少了。这些结果表明 B可以共同感染小鼠。 burgdorferi 和HGE试剂可调节宿主的免疫反应，从而增加细菌负担，莱姆关节炎和病原体向载体的传播。

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