Relationship between Candida albicans Virulence during Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage In Vitro

Angela A. Sanchez; Douglas A. Johnston; Carter Myers; John E. Edwards; Aaron P. Mitchell; Scott G. Filler

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Relationship between Candida albicans Virulence during Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage In Vitro

机译：实验性血行播散性感染中白色念珠菌毒力与体外内皮细胞损伤之间的关系

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Candida albicans must penetrate the endothelial cell lining of the vasculature to invade the deep tissues during a hematogenously disseminated infection. We compared 27 C. albicans mutants with their wild-type parent for their capacity to damage endothelial cells in vitro and cause a lethal infection in mice following tail vein inoculation. Of 10 mutants with significantly impaired capacity to damage endothelial cells, all had attenuated virulence. Therefore, the endothelial cell damage assay can be used as a screen to identify some virulence factors relevant to hematogenously disseminated candidiasis.

机译：在血行播散性感染期间，白色念珠菌必须穿透脉管系统的内皮细胞内膜以侵入深层组织。我们比较了27个C。带有野生型亲本的白色念珠菌突变体具有体外破坏内皮细胞并在小鼠尾静脉接种后在小鼠中引起致命感染的能力。在破坏内皮细胞能力显着受损的10个突变体中，所有突变体的毒力均已减弱。因此，内皮细胞损伤测定法可用作筛选，以鉴定一些与血源性传播的念珠菌病有关的毒力因子。 展开▼

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《Infection and immunity》 |2004年第1期|共4页

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Angela A. Sanchez; Douglas A. Johnston; Carter Myers; John E. Edwards; Aaron P. Mitchell; Scott G. Filler;
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中图分类医学免疫学;

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1. Physiologic Expression of the Candida albicans Pescadillo Homolog Is Required for Virulence in a Murine Model of Hematogenously Disseminated Candidiasis [J] . Priya Uppuluri, Ashok K. Chaturvedi, Niketa Jani, Eukaryotic cell . 2012,第12期

机译：白色念珠菌Pescadillo同系物的生理表达是血源性传播念珠菌病小鼠模型中的毒力所必需的。

2. Limited Role of Secreted Aspartyl Proteinases Sap1 to Sap6 in Candida albicans Virulence and Host Immune Response in Murine Hematogenously Disseminated Candidiasis [J] . Alexandra Correia, Ulrich Lermann, Luzia Teixeira, Infection and immunity . 2010,第11期

机译：分泌的天冬氨酰蛋白酶Sap1至Sap6在白色念珠菌毒力和宿主血源性念珠菌病宿主免疫反应中的作用有限。

3. A Competitive Infection Model of Hematogenously Disseminated Candidiasis in Mice Redefines the Role of Candida albicans IRS4 in Pathogenesis [J] . Suresh B. Raman, M. Hong Nguyen, Shaoji Cheng, Infection and immunity . 2013,第5期

机译：小鼠血行传播念珠菌病的竞争性感染模型重新定义了白色念珠菌IRS4在发病机理中的作用。

4. Effect of Implant Disinfection by Antimicrobial Photodynamic Therapy (aPDT) on in vitro Candida albicans biofilm [C] . Betania Maria Spares, Danielle Leticia Silva, Thais Furtado Ferreira Magalhaes, World biomaterials congress . 2012

机译：抗菌素光动力疗法（aPDT）对种植体的消毒作用对体外白色念珠菌生物膜的影响

5. In Vitro Evaluation of Candida albicans Adherence and Disinfection Techniques on CAD/CAM Milled, 3D Printed, and Heat-Cured PMMA [D] . Koujan, Amir. 2020

机译：CAD / CAM铣削，3D印刷和热固化PMMA的CADIVA albicans对CAD / CAM的粘附和消毒技术的体外评价

6. Relationship between Candida albicans Virulence during Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage In Vitro [O] . Angela A. Sanchez, Douglas A. Johnston, Carter Myers, 2004

机译：实验性血行播散性感染期间白色念珠菌毒力与体外内皮细胞损伤之间的关系

7. Relationship between Candida albicans Virulence during Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage In Vitro [O] . Sanchez, Angela A., Johnston, Douglas A., Myers, Carter, 2004

机译：实验性血行播散性感染期间白色念珠菌毒力与体外内皮细胞损伤之间的关系

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3. Nucleic acid and amino acid sequences of hemoglobin-response genes in Candida albicans and the use of reagents derived from these sequences in the diagnosis of disseminated Candida albicans infection [P] . 外国专利： US7332167B2 . 2008-02-19

机译：白色念珠菌血红蛋白反应基因的核酸和氨基酸序列以及从这些序列衍生的试剂在诊断白色念珠菌传播中的应用

4. nucleic acid and amino acid sequences of induzierbaren - haemoglobin genes from candida albicans and the use of these sequences in the diagnosis of disseminated reagents candida albicans infection [P] . 外国专利： DE60035857D1 . 2007-09-20

机译：念珠菌白色念珠菌-血红蛋白基因的核酸和氨基酸序列及其在诊断白色念珠菌传播试剂中的应用

5. nucleic acid and amino acid sequences of induzierbaren - haemoglobin genes from candida albicans and the use of these sequences in the diagnosis of disseminated reagents candida albicans infection [P] . 外国专利： AT369426T . 2007-08-15

机译：念珠菌白色念珠菌-血红蛋白基因的核酸和氨基酸序列及其在诊断白色念珠菌传播试剂中的应用

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Relationship between Candida albicans Virulence during Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage In Vitro

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