...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Production and characterization of serovar-specific monoclonal antibodies to serovars 4, 8, and 9 of Mycobacterium intracellulare.
【24h】

Production and characterization of serovar-specific monoclonal antibodies to serovars 4, 8, and 9 of Mycobacterium intracellulare.

机译：针对胞内分枝杆菌的血清4、8和9的血清型特异性单克隆抗体的生产和表征。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Serovar-specific monoclonal antibodies against Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum complex serovars 4, 8, and 9 were prepared. Nine, four, and one monoclonal antibodies, respectively, to the serovars were prepared by the usual cell fusion technique. All nine monoclonal antibodies to serovar 4 were monospecific for their homologous serovar and reacted with several native glycopeptidolipids (GPLs) and one major deacylated GPL from the homologous serovar. One of the four monoclonal antibodies to serovar 8 seemed to be monospecific for its homologous serovar, but the other cross-reacted with serovar 6 because serovar 6 organisms contain the same components as does the major deacylated GPL from serovar 8. One monoclonal antibody to serovar 9 was monospecific for its homologous serovar and reacted with one of the two major deacylated GPLs from this serovar. These antibody preparations proved useful for serovar identification.
机译：制备了抗鸟分枝杆菌-胞内分枝杆菌-阴囊分枝杆菌复合物血清型4、8和9的血清型特异性单克隆抗体。通过常规的细胞融合技术分别制备了针对血清的九种，四种和一种单克隆抗体。血清型4的所有九种单克隆抗体均对它们的同源血清型具有特异性，并且与同源血清型的几种天然糖肽脂质（GPL）和一种主要的去酰化GPL反应。血清型8的四种单克隆抗体之一似乎对其同源血清型具有单特异性，但另一种则与血清型6发生交叉反应，因为血清型6微生物与血清型8的主要脱酰基GPL所含成分相同。 9是其同源血清型的单特异性抗体，并且与来自该血清型的两个主要的脱酰基GPL之一反应。这些抗体制剂被证明可用于血清型鉴定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号