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首页> 外文期刊>Infection and immunity >Protective efficacy in humans of killed whole-vibrio oral cholera vaccine with and without the B subunit of cholera toxin.
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Protective efficacy in humans of killed whole-vibrio oral cholera vaccine with and without the B subunit of cholera toxin.

机译：具有和不具有霍乱毒素B亚基的灭活全弧菌口服霍乱疫苗对人的保护功效。

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Natural protection from cholera is associated with local intestinal antibacterial and antitoxic antibodies, which appear to act synergistically. Although current parenteral cholera vaccines offer insufficient protection, new vaccines administered orally have more promise. Killed Vibrio cholerae, alone or given with the B subunit of cholera toxin, was evaluated in adult volunteers. Vaccinees, who received three doses of either vaccine, and unvaccinated controls ingested 10(6) V. cholerae organisms to determine the protective efficacy of the vaccines. The combination vaccine provided 64% protection, and the whole vibrio vaccine given alone provided 56% protection. In addition, illnesses in vaccines were milder than those in controls, and both vaccines gave complete protection against more severe disease. This substantial level of protection against a dose of V. cholerae that caused cholera in nearly 90% of controls suggests that these vaccines might provide at least as high a level of protection if given to the population of an endemic area. Indeed, a field efficacy trial is underway in Bangladesh, and preliminary data indicate a protective efficacy of 85% for a killed whole vibrio plus B subunit vaccine similar to that tested in volunteers and an efficacy of 58% for the killed whole vibrio vaccine alone. Thus, the studies in human volunteers were successful in predicting the substantial protection afforded by the vaccines in a cholera endemic area.
机译：对霍乱的天然保护与局部肠道抗菌和抗毒性抗体有关，这些抗体似乎具有协同作用。尽管当前的肠胃外霍乱疫苗不能提供足够的保护，但是口服新疫苗具有更大的前景。在成年志愿者中评估了单独杀死霍乱弧菌或与霍乱毒素B亚基一起给予的霍乱弧菌。接受三剂任一疫苗的疫苗接种者和未接种疫苗的对照者摄入10（6）霍乱弧菌生物，以确定疫苗的保护功效。组合疫苗提供了64％的保护，而单独提供的整个弧菌疫苗则提供了56％的保护。此外，疫苗中的疾病比对照中的疾病要轻，并且两种疫苗都可以提供针对更严重疾病的完全保护。在将近90％的对照中，对引起霍乱的霍乱弧菌剂量的这种实质性保护水平表明，如果将这些疫苗提供给地方病地区的人群，其保护水平至少可以达到相同水平。确实，孟加拉国正在进行一项现场功效试验，初步数据表明，对灭活的完整弧菌加B亚单位疫苗的保护功效与志愿者测试的相似，而对灭活的完整弧菌疫苗的保护功效为58％。因此，在人类志愿者中的研究成功地预测了霍乱流行地区疫苗所提供的实质性保护。

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