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首页> 外文期刊>Infection and immunity >Recombinant murine gamma interferon induces enhanced resistance to Listeria monocytogenes infection in neonatal mice.
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Recombinant murine gamma interferon induces enhanced resistance to Listeria monocytogenes infection in neonatal mice.

机译：重组鼠γ干扰素诱导新生小鼠对单核细胞增多性李斯特菌感染的抵抗力增强。

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Neonatal mice within 24 h of birth were highly susceptible to intraperitoneal infection with Listeria monocytogenes. The 50% lethal dose of bacterial cells was 6.3 X 10(1) CFU for neonates and 3.2 X 10(6) CFU for adult mice. A single injection of recombinant murine gamma interferon (rMuIFN-gamma) protected neonatal mice from simultaneous challenge with a lethal dose of L. monocytogenes cells. The rMuIFN-gamma effect was dose dependent: protection was consistently observed in mice treated with rMuIFN-gamma at doses of more than 4 X 10(2) U (0.1 microgram of protein) per mouse. Bacterial growth in the spleens and livers of rMuIFN-gamma-treated neonates was significantly suppressed in comparison with that in the nontreated controls. The infected neonatal mice showed acquired antilisterial resistance against secondary intravenous infection after 4 weeks of age, and this resistance was significantly augmented in mice that had been treated with rMuIFN-gamma.
机译：出生后24小时内的新生小鼠高度易受腹膜内李斯特菌感染。细菌细胞的50％致死剂量对于新生儿是6.3 X 10（1）CFU，对于成年小鼠是3.2 X 10（6）CFU。单次注射重组鼠γ干扰素（rMuIFN-γ）可以保护新生小鼠免受致死剂量的单核细胞增生李斯特氏菌细胞的同时攻击。 rMuIFN-γ的作用是剂量依赖性的：在每只小鼠用大于4 X 10（2）U（0.1微克蛋白质）的剂量用rMuIFN-γ处理的小鼠中，始终观察到保护作用。与未治疗的对照组相比，rMuIFN-γ治疗的新生儿的脾脏和肝脏中的细菌生长受到显着抑制。感染的新生小鼠在4周龄后显示出对继发性静脉内感染的获得性抗李斯特菌耐药性，并且在用rMuIFN-γ治疗的小鼠中，这种耐药性显着增强。

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