Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast-to-mycelium transition in Candida albicans.

M Casanova; J P Martínez; W L Chaffin

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Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast-to-mycelium transition in Candida albicans.

机译：来自针对生殖管甘露聚糖蛋白的单克隆抗体的Fab片段阻断了白色念珠菌中的酵母向菌丝体的转化。

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Fab fragments prepared from the immunoglobulin G monoclonal antibody (MAb) 4C12, which reacts with a determinant expressed on the hyphal extension of germ tubes of Candida albicans, inhibited germ tube formation, but intact MAb 4C12 did not. Indirect immunofluorescence showed a punctate binding pattern on cells incubated with Fab fragments but a confluent binding on cells incubated with intact MAb 4C12.

机译：由免疫球蛋白G单克隆抗体（MAb）4C12制备的Fab片段与在白色念珠菌的细菌管的菌丝延伸上表达的决定簇反应，抑制了细菌管的形成，但完整的MAb 4C12却没有。间接免疫荧光显示与Fab片段孵育的细胞具有点状结合模式，但与完整MAb 4C12孵育的细胞具有汇合性结合。

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《Infection and immunity》 |1990年第11期|共3页
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M Casanova; J P Martínez; W L Chaffin;
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中图分类医学免疫学;
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专利

1. Antigenic differences between mannoproteins of germ tubes and blastospores of Candida albicans. [J] . P M Sundstrom, E J Nichols, G E Kenny Infection and immunity . 1987,第3期

机译：生殖管甘露糖蛋白和白色念珠菌芽孢之间的抗原差异。
2. Antifungal and antitumor activities of a monoclonal antibody directed against a stress mannoprotein of Candida albicans. [J] . Omaetxebarria MJ, Moragues MD, Elguezabal N, Current molecular medicine . 2005,第4期

机译：针对白色念珠菌应激甘露糖蛋白的单克隆抗体的抗真菌和抗肿瘤活性。
3. Preparation and characterization of a monoclonal antibody against mannoprotein of Candida albicans. [J] . Farahnejad Z, Rasaee MJ, Moghadam MF, Hybridoma . 2005,第3期

机译：抗白色念珠菌甘露糖蛋白单克隆抗体的制备和表征。
4. AN OPTIMAL CONJUGATE VACCINE FOR CANDIDA ALBICANS BY REVERSE ENGINEERING A MONOCLONAL ANTIBODY [C] . David R. Bundle, Margaret A. Johnson, Tomas Lipinski International Carbohydrate Symposium . 2013

机译：逆向工程丹丹醛肽的最佳缀合物疫苗，单克隆抗体
5. Fab fragments of monoclonal antibodies directed against HER2 /neu or tumor-associated glycoprotein-72 for radioimmunodetection of breast cancer [D] . Tang, Ying 2005

机译：针对HER2 / neu或肿瘤相关糖蛋白-72的单克隆抗体的Fab片段，用于乳腺癌的放射免疫检测
6. Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast-to-mycelium transition in Candida albicans. [O] . M Casanova, J P Martínez, W L Chaffin 1990

机译：来自针对生殖管甘露聚糖蛋白的单克隆抗体的Fab片段阻断了白色念珠菌中的酵母到菌丝体的转化。
7. Recognition of Candida albicans Als3 by the germ tube-specific monoclonal antibody 3D9.3 [O] . B. Beucher, A. Marot, S. Nail-Billaud, 2009

机译：用胚芽管特异性单克隆抗体3D9.3识别白色念珠菌als3
8. Novel Recombinant Fab Fragments of the Tag-72 Monoclonal Antibody CC49 Containing an Integrated Radiometal Binding Site for Radioimmunoguided Surgery for DCIS [R] . Teng, Y. 2004

机译：新型重组Fab片段的Tag-72单克隆抗体CC49含有整合的放射性金属结合位点，用于DCIs的放射免疫导向手术

Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast-to-mycelium transition in Candida albicans.

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