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首页> 外文期刊>Infection and immunity >Vaccination of mice with a soluble protein fraction of Mycobacterium leprae provides consistent and long-term protection against M. leprae infection.
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Vaccination of mice with a soluble protein fraction of Mycobacterium leprae provides consistent and long-term protection against M. leprae infection.

机译：用麻风分枝杆菌的可溶蛋白级分对小鼠进行疫苗接种可对麻风分枝杆菌感染提供一致的长期保护。

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Groups of BALB/c mice were vaccinated intradermally with either Freund's incomplete adjuvant (FIA) alone, 10(7) heat-killed Mycobacterium leprae organisms in FIA, or a number of fractions of M. leprae containing soluble and/or cell wall components. At 1, 3, 6, 9, and 12 months later, vaccinated mice were challenged in the right hind footpad with 5,000 live M. leprae organisms, and vaccine protection was assessed 6 to 8 months later, at the peak of M. leprae multiplication in the negative control (FIA alone), by the two-sample rank-sum test. In these studies, a cell wall fraction rich in peptidoglycan was consistently ineffective. Both heat-killed M. leprae and a fraction containing cell wall and fixed proteins generally protected when the interval between vaccination and challenge was 1 or 3 months but not subsequently. On the other hand, soluble proteins of M. leprae alone or in combination (with cell wall fractions) consistently (14 of 14 instances) afforded highly significant protection (P less than or equal to 0.01) at all challenge intervals up to 1 year after vaccination. These results suggest that the soluble protein fraction of M. leprae offers promise for a vaccine against leprosy.
机译：将BALB / c小鼠组皮内接种单独的弗氏不完全佐剂（FIA），FIA中的10（7）个热灭活的麻风分枝杆菌有机体或许多含有可溶性和/或细胞壁成分的麻风分支杆菌。在第1、3、6、9和12个月后，在右后足垫中接种了5,000种活的麻风杆菌，对接种疫苗的小鼠进行了攻击，并在麻风杆菌繁殖高峰时的6至8个月评估了疫苗的保护性。在阴性对照中（单独使用FIA），通过两次样本秩和检验。在这些研究中，富含肽聚糖的细胞壁部分一直无效。当疫苗接种和攻击之间的间隔为1或3个月，但随后没有保护时，热杀死的麻风分枝杆菌和含有细胞壁和固定蛋白的部分通常都得到保护。另一方面，麻风分枝杆菌的可溶性蛋白单独或组合（与细胞壁组分结合使用）（14个实例中的14个）在长达1年的所有攻击间隔中均提供高度显着的保护（P小于或等于0.01）。疫苗接种。这些结果表明麻风分枝杆菌的可溶性蛋白部分为抗麻风病疫苗提供了希望。

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