Endogenous gamma interferon mediates resistance to Brucella abortus infection.

Y Zhan; C Cheers

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Endogenous gamma interferon mediates resistance to Brucella abortus infection.

机译：内源性γ干扰素介导了对流产布鲁氏菌感染的抗性。

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Depletion of endogenous gamma interferon (IFN-gamma) with anti-IFN-gamma monoclonal antibody resulted in increased numbers of Brucella abortus in the spleen and liver of infected CBA mice. This increase was accompanied by a decrease in splenomegaly and a lower proportion of macrophages in the spleen. Furthermore, treatment of recipient mice with anti-IFN-gamma antibody blocked the adoptive transfer of resistance with immune T cells. Together, the results indicated that endogenous IFN-gamma plays an important role in mediating resistance to primary and secondary Brucella infection.

机译：用抗-IFN-γ单克隆抗体消耗内源性γ-干扰素（IFN-γ）导致感染的CBA小鼠的脾脏和肝脏中流产布鲁氏菌的数量增加。这种增加伴随着脾肿大的减少和脾脏中巨噬细胞比例的降低。此外，用抗IFN-γ抗体治疗受体小鼠可以阻止免疫T细胞的抗性过继转移。总之，结果表明内源性IFN-γ在介导对原发性和继发性布鲁氏菌感染的抗性中起重要作用。

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《Infection and immunity》 |1993年第11期|共3页
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Y Zhan; C Cheers;
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中图分类医学免疫学;
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1. Endogenous interleukin-12 is involved in resistance to Brucella abortus infection. [J] . Y Zhan, C Cheers Infection and immunity . 1995,第4期

机译：内源性白介素12参与对布鲁氏菌流产感染的抵抗。
2. Importance of endogenous tumor necrosis factor alpha and gamma interferon in host resistance against Pneumocystis carinii infection. [J] . W Chen, E A Havell, A G Harmsen Infection and immunity . 1992,第4期

机译：内源性肿瘤坏死因子α和γ干扰素在抗卡氏肺孢子虫感染宿主抗性中的重要性。
3. Investigating the Use of Protein Saver Cards for Storage and Subsequent Detection of Bovine Anti-Brucella abortus Smooth Lipopolysaccharide Antibodies and Gamma Interferon [J] . Lucy Duncombe, Nicola J. Commander, Sevil Erdenlig, Clinical and vaccine immunology: CVI . 2013,第11期

机译：研究使用蛋白质保护卡存储和随后检测牛抗小儿流产布鲁氏菌平滑脂多糖抗体和γ干扰素
4. Enhanced killing of intracellular Brucella abortus by antibiotic-loaded polyanhydride nanoparticles [C] . Paul Lueth, Yashdeep Phanse, Shannon Haughney AIChE Annual Meeting . 2014

机译：通过抗生素负载的多烷氢化物纳米颗粒增强了细胞内布鲁氏菌杀菌
5. The Functions of Autophagy Genes and Interferon Regulatory Factor 1 in Interferon Gamma Mediated Control of Murine Norovirus Infection. [D] . Maloney, Nicole Samantha. 2013

机译：自噬基因和干扰素调节因子1在干扰素γ介导的鼠诺如病毒感染控制中的功能。
6. Endogenous gamma interferon mediates resistance to Brucella abortus infection. [O] . Y Zhan, C Cheers 1993

机译：内源性γ干扰素介导对流产布鲁氏菌感染的抗性。
7. Endogenous gamma interferon mediates resistance to Brucella abortus infection [O] . Y Zhan, C Cheers 1993

机译：内源性伽马干扰素介导耐药于Brucella abortus感染
8. T-Independent Responses in B Cell-Defective CBA/N Mice to 'Brucella abortus' and to Trinitrophenyl (TNP) Conjugates of 'Brucella abortus'. [R] . Mond, J. J., Scher, I., Mosier, D. E., 1978

机译：B细胞缺陷型CBa / N小鼠对'流产布鲁氏菌'和'布鲁氏菌流产'的三硝基苯基（TNp）缀合物的T非依赖性反应。

Endogenous gamma interferon mediates resistance to Brucella abortus infection.

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