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首页> 外文期刊>Infection and immunity >T-cell-mediated immunity in persistent Mycobacterium intracellulare infections in mice.
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T-cell-mediated immunity in persistent Mycobacterium intracellulare infections in mice.

机译：小鼠持续性分枝杆菌胞内感染中T细胞介导的免疫力。

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Growth of mouse-virulent Mycobacterium intracellulare D673 and TMC 1405 in the lung was affected by T-cell depletion in susceptible C57BL/6 mice. Significant differences also occurred between the growth patterns seen in congenitally athymic (nuu) mice and their nu/+ littermates. Treatment of the mice with an immunosuppressive regimen of cyclosporin A (75 mg/kg of body weight per day subcutaneously) provided further evidence of the importance of T cells in controlling growth of M. intracellulare in the normal host. Adoptive transfer experiments indicated the presence of a T-cell-mediated specific protective immunity against a subsequent M. intracellulare challenge when transfer was carried out 3 weeks after immunization of the donor host. At this time, cross-protective immunity was also observed against a virulent M. tuberculosis challenge. There was no difference in the rate of growth by M. intracellulare as challenge in Mycobacterium bovis BCG-activated or normal peritoneal macrophages from C57BL/6 mice tested in vitro during a 7-day period. However, M. tuberculosis growth rates were decreased substantially in the BCG-activated macrophages. These studies suggest that mice infected with M. intracellulare do not eliminate the infection, because this organism can resist the bactericidal activity of the T-cell-activated macrophage better than M. tuberculosis can.
机译：易感染的C57BL / 6小鼠中，T细胞耗竭影响了小鼠毒性的胞内分枝杆菌D673和TMC 1405在肺中的生长。在先天性无胸腺（nu / nu）小鼠与其nu / +同窝仔小鼠中观察到的生长模式之间也发生了显着差异。用环孢菌素A的免疫抑制方案（皮下每天每天75 mg / kg体重）治疗小鼠，提供了T细胞在控制正常宿主中胞内分枝杆菌生长中的重要性的进一步证据。过继转移实验表明，在免疫供体宿主后3周进行转移时，存在针对随后的胞内分枝杆菌攻击的T细胞介导的特异性保护性免疫。此时，还观察到针对有毒结核分枝杆菌攻击的交叉保护性免疫。在7天内体外测试的牛分枝杆菌BCG激活的C57BL / 6小鼠的正常腹膜巨噬细胞或正常腹膜巨噬细胞中，胞内分枝杆菌的生长速率没有差异。但是，在BCG活化的巨噬细胞中结核分枝杆菌的生长速度大大降低。这些研究表明，感染了胞内分枝杆菌的小鼠不能消除感染，因为这种微生物比结核分枝杆菌能更好地抵抗T细胞活化巨噬细胞的杀菌活性。

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