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首页> 外文期刊>Infection and immunity >Association of Campylobacter pylori with induced expression of class II transplantation antigens on gastric epithelial cells.
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Association of Campylobacter pylori with induced expression of class II transplantation antigens on gastric epithelial cells.

机译：幽门弯曲杆菌与胃上皮细胞诱导的II类移植抗原表达的关联。

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摘要

Campylobacter pylori was identified with immunoperoxidase staining and a mouse monoclonal antibody directed against C. pylori in gastric biopsy specimens from 24 patients with gastritis. C. pylori was not found in gastric biopsy specimens from six subjects with histologically normal mucosa. The monoclonal antibody, which was reactive with a surface protein of approximately 20 kilodaltons, was found to be specific for C. pylori, and the immunoperoxidase staining proved to be more sensitive and rapid than culture in detecting the organism. In the tissue specimens where C. pylori was detected with the monoclonal antibody, there was a strong expression of class II transplantation antigens on the epithelial cells and an increased number of T lymphocytes. These findings indicate that C. pylori may initiate local immune responses.
机译：通过免疫过氧化物酶染色和针对24例胃炎患者胃活检标本中的针对幽门螺杆菌的小鼠单克隆抗体，鉴定了幽门弯曲杆菌。在组织学正常的粘膜的六个受试者的胃活检标本中未发现幽门螺旋杆菌。已发现与约20道尔顿的表面蛋白有反应性的单克隆抗体对幽门螺杆菌具有特异性，并且在检测生物体时，免疫过氧化物酶染色被证明比培养更敏感，更快速。在用单克隆抗体检测到幽门螺旋杆菌的组织标本中，II类移植抗原在上皮细胞中强烈表达，T淋巴细胞数量增加。这些发现表明幽门螺杆菌可能启动局部免疫反应。

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