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首页> 外文期刊>Infection and immunity >Penicillin treatment accelerates middle ear inflammation in experimental pneumococcal otitis media.
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Penicillin treatment accelerates middle ear inflammation in experimental pneumococcal otitis media.

机译：青霉素治疗可加速实验性肺炎球菌性中耳炎的中耳炎症。

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Most Streptococcus pneumoniae strains are killed by very low concentrations of penicillin and other beta-lactam antibiotics, yet middle ear inflammation and effusion persist for days to weeks after treatment in most cases of pneumococcal otitis media. To study the effect of beta-lactam antibiotic treatment on pneumococci and the middle ear inflammatory response during pneumococcal otitis media, we measured concentrations of pneumococci, inflammatory cells, and lysozyme in middle ear fluid (MEF) by using the chinchilla model. Procaine penicillin G given intramuscularly 12 and 36 h after inoculation of pneumococci into the middle ear caused a significant acceleration in the MEF inflammatory cell concentration compared with that in untreated controls, with a significant peak in the inflammatory cell concentration 24 h after pneumococcal inoculation. The lysozyme concentration in MEF also increased more rapidly in treated than in control animals. Viable pneumococci were not detected in MEF after the second dose of penicillin, but the total pneumococcal cell concentration remained unchanged for at least 45 days. Therefore, penicillin treatment accelerated middle ear inflammation while killing pneumococci, but treatment did not accelerate clearance of the nonviable pneumococcal cells from MEF. Further studies will need to define the contribution of these responses to acute and chronic tissue injury.
机译：大多数肺炎链球菌菌株被极低浓度的青霉素和其他β-内酰胺抗生素杀死，但在大多数肺炎球菌性中耳炎治疗后，中耳发炎和积液持续数天至数周。为了研究β-内酰胺类抗生素治疗对肺炎球菌性中耳炎期间肺炎球菌和中耳炎性反应的影响，我们使用黄鼠模型测量了中耳液（MEF）中肺炎球菌，炎性细胞和溶菌酶的浓度。肺炎球菌接种到中耳后12和36小时肌内注射普鲁卡因青霉素G与未治疗的对照组相比，引起MEF炎性细胞浓度显着加速，肺炎球菌接种后24 h炎性细胞浓度出现显着峰值。与对照动物相比，经治疗的MEF中的溶菌酶浓度也更快地增加。在第二剂青霉素后，MEF中未检测到活的肺炎球菌，但至少45天，总的肺炎球菌细胞浓度保持不变。因此，青霉素治疗在杀死肺炎球菌的同时加速了中耳炎症，但治疗并未加速从MEF清除无活性肺炎球菌细胞的过程。进一步的研究将需要确定这些反应对急性和慢性组织损伤的贡献。

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