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首页> 外文期刊>Infection and immunity >The maltose regulon of Vibrio cholerae affects production and secretion of virulence factors.
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The maltose regulon of Vibrio cholerae affects production and secretion of virulence factors.

机译：霍乱弧菌的麦芽糖调节剂影响毒力因子的产生和分泌。

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The effects of maltose on production and secretion of virulence factors of Vibrio cholerae in strain X28214, classical biotype, and in maltose-defective transposon mutants constructed from this strain were characterized. Maltose was found to inhibit secretion of cholera toxin and to reduce production of the mannose-sensitive hemagglutinin and the soluble hemagglutinin-protease. In contrast, the amount of toxin-coregulated pilus was increased in the presence of maltose. The maltose effect was apparently mediated by genes of the maltose regulon, since inactivation of the malQ or malF gene of V. cholerae by transposon insertion was found to affect production and secretion of the same virulence factors that were responsive to maltose. The malQ and malF mutants showed, in addition, reduced virulence in an infant-mouse model. These results suggest that maltose may have a significant regulatory role in the production of virulence factors and that an intact maltose regulon is needed for full virulence of V. cholerae.
机译：表征了麦芽糖对X28214菌株，经典生物型以及由该菌株构建的麦芽糖缺陷型转座子突变体中霍乱弧菌的产生和分泌毒力因子的影响。发现麦芽糖抑制霍乱毒素的分泌并减少对甘露糖敏感的血凝素和可溶性血凝素蛋白酶的产生。相反，在麦芽糖的存在下，毒素结合菌毛的量增加。麦芽糖的作用显然是由麦芽糖调节子的基因介导的，因为发现通过转座子插入使霍乱弧菌的malQ或malF基因失活会影响同样对麦芽糖有反应力的毒力因子的产生和分泌。此外，malQ和malF突变体在婴儿小鼠模型中显示出降低的毒力。这些结果表明，麦芽糖在毒力因子的产生中可能具有重要的调节作用，并且完整的麦芽糖调节剂对于霍乱弧菌的完全毒力是必需的。

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