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Cellular responses to a 55-kilodalton recombinant Pneumocystis carinii antigen.

机译：细胞对55公斤级重组卡氏肺孢子虫抗原的反应。

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The host-parasite interaction in Pneumocystis carinii pneumonia is poorly understood. In recent years, two major groups of P. carinii antigens have been identified. One class of antigens is characterized by a broad band of immunoreactivity between 45 and 55 kDa in P. carinii derived from rats. This antigen complex is the P. carinii antigen most commonly found in respiratory tract specimens and most frequently recognized by the host immune response. The availability of a recombinant antigen has permitted studies focusing on the cellular and humoral responses to a single antigen within this class, p55. In this study, we have demonstrated that the p55 antigen elicits a cell-mediated immune response in animals previously exposed to P. carinii. Under conditions of natural exposure, the 5' portion of the molecule, p55(1-200), appears immunologically silent, failing to elicit lymphocyte proliferation or cytokine secretion. Following active immunization, the 5' portion is capable of stimulating lymphocyte proliferation. The 3' portion, p55(268-414), has at least one immunodominant region which contains a 7-amino-acid repeat motif. The cells responding to p55 include a CD4+ T cell which secretes a Th1 cytokine pattern. A detailed understanding of the host-parasite interaction will facilitate the development of immunoprophylaxis and immunotherapy for P. carinii infection.
机译：卡氏肺孢子虫肺炎中宿主与寄生虫的相互作用了解甚少。近年来，已经鉴定出两大类卡氏疟原虫抗原。一类抗原的特征是在源自大鼠的卡氏疟原虫中在45至55 kDa之间具有广泛的免疫反应性。这种抗原复合物是卡氏疟原虫抗原，最常在呼吸道标本中发现，最常被宿主免疫应答识别。重组抗原的可用性已使研究集中于针对此类p55中单个抗原的细胞和体液反应。在这项研究中，我们已经证明p55抗原在先前暴露于卡氏疟原虫的动物中引发细胞介导的免疫反应。在自然暴露条件下，该分子的5'部分p55（1-200）在免疫学上表现为沉默，无法引起淋巴细胞增殖或细胞因子分泌。主动免疫后，5'部分能够刺激淋巴细胞增殖。 3′部分，p55（268-414），具有至少一个包含7个氨基酸重复基序的免疫显性区域。响应p55的细胞包括分泌Th1细胞因子模式的CD4 + T细胞。对宿主-寄生虫相互作用的详细了解将有助于发展对卡氏疟原虫感染的免疫预防和免疫疗法。

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