Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle.

T C Ushe; G H Palmer; L Sotomayor; J V Figueroa; G M Buening; L E Perryman; T F McElwain

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Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle.

机译：免疫牛中对巴贝斯虫双歧杆菌rhoptry相关蛋白1表面暴露和中和敏感表位的抗体反应。

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Protective immunity against Babesia bigemina is hypothesized to involve antibodies directed against merozoite surface-exposed epitopes. Levels of antibody against a rhoptry-associated protein 1 (RAP-1) B-lymphocyte epitope, defined by surface-reactive and inhibitory monoclonal antibodies, in immune cattle sera were determined. All cattle produced antibodies to the epitope; however, there was limited correlation between immune protection induced by infection or RAP-1 immunization and the level of antibody to the neutralization-sensitive B-lymphocyte epitope examined.

机译：据推测，针对Babesia bigemina的保护性免疫涉及针对裂殖子表面暴露表位的抗体。确定了在免疫牛血清中针对与rhoptry相关蛋白1（RAP-1）B淋巴细胞抗原决定簇的抗体的水平，该抗体由表面反应性和抑制性单克隆抗体定义。所有牛都产生针对表位的抗体;然而，在感染或RAP-1免疫诱导的免疫保护与中和敏感性B淋巴细胞表位的抗体水平之间的相关性有限。

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《Infection and immunity》 |1994年第12期|共4页
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T C Ushe; G H Palmer; L Sotomayor; J V Figueroa; G M Buening; L E Perryman; T F McElwain;
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1. Babesia bovis merozoite surface protein-2c (MSA-2c) contains highly immunogenic, conserved B-cell epitopes that elicit neutralization-sensitive antibodies in cattle. [J] . Wilkowsky SE, Farber M, Echaide I, Molecular and Biochemical Parasitology . 2003,第2期

机译：牛杆状裂殖子裂殖子表面蛋白2c（MSA-2c）含有高度免疫原性的保守B细胞表位，可引起牛的中和敏感性抗体。
2. Identification of Babesia bigemina and Babesia bovis merozoite proteins with isolate- and species-common epitopes recognized by antibodies in bovine immune sera. [J] . T F McElwain, G H Palmer, W L Goff, Infection and immunity . 1988,第6期

机译：用牛免疫血清中的抗体识别的分离物和物种常见表位鉴定大巴贝虫和牛巴贝斯牛裂殖子蛋白。
3. Identification of Babesia bigemina and Babesia bovis merozoite proteins with isolate- and species-common epitopes recognized by antibodies in bovine immune sera. [J] . T F McElwain, G H Palmer, W L Goff, Infection and immunity . 1988,第6期

机译：用牛免疫血清中的抗体识别的分离物和物种常见表位鉴定大巴贝虫和牛巴贝斯牛裂殖子蛋白。
4. DIFFERENTIAL ANTIBODY RESPONSE AGAINST CONFORMATIONAL AND LINEAR EPITOPES OF THE L1 PROTEIN FROM HUMAN PAPILLOMAVIRUS TYPES 16/18 IS GENERATED IN VACCINATED WOMAN OR WITH DIFFERENT EXPOSURES TO THE VIRUS. [C] . Gutierrez-Xicotencatl L, Pedroza-Saavedra A, Rodriguez-Ocampo AN, Vaccine technology VI . 2016

机译：针对人乳头瘤病毒类型16/18的L1蛋白质的构象和线性表位产生的不同抗体反应是在疫苗接种的妇女中产生的，或在与病毒的不同接触中产生的。
5. Effect of porcine reproductive and respiratory syndrome virus non-structure protein 2 epitope deletion mutants on the induction of host immune responses. [D] . Zhou, Xiaoxin. 2009

机译：猪繁殖与呼吸综合征病毒非结构蛋白2表位缺失突变体对诱导宿主免疫反应的影响。
6. Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle. [O] . T C Ushe, G H Palmer, L Sotomayor, 1994

机译：免疫牛中对巴贝斯虫双歧杆菌rhoptry相关蛋白1表面暴露和中和敏感表位的抗体反应。
7. Immunodominant Epitopes in Babesia bovis Rhoptry-Associated Protein 1 That Elicit Memory CD4+-T-Lymphocyte Responses in B. bovis-Immune Individuals Are Located in the Amino-Terminal Domain [O] . Norimine, Junzo, Suarez, Carlos E., McElwain, Terry F., 2002

机译：牛念珠菌Rhoptry相关蛋白1的免疫抗原决定簇，其在牛念珠菌免疫个体中引起记忆CD4 + -T淋巴细胞反应位于氨基末端结构域
8. Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope based DNA vaccine able to focus the antibody response in mice. [R] . Schmaljohn, C. 2017

机译：埃博拉病毒显性和次优势糖蛋白表位的表位作图有助于构建能够将抗体反应集中在小鼠中的基于表位的DNa疫苗。

Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle.

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