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首页> 外文期刊>Infection and immunity >Legionella pneumophila growth restriction and cytokine production by murine macrophages activated by a novel Pseudomonas lipid A.
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Legionella pneumophila growth restriction and cytokine production by murine macrophages activated by a novel Pseudomonas lipid A.

机译：新型假单胞菌脂质A激活的小鼠巨噬细胞对肺炎军团菌的生长限制和细胞因子的产生。

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Peritoneal exudate macrophages from A/J mice activated by purified lipid A preparations from Pseudomonas vesicularis, which contain 2,3-diamino-2,3-dideoxy-D-glucose disaccharide phosphomonoester as the lipid A backbone, restricted the growth of Legionella pneumophila, an intracellular opportunistic bacteria which readily grows in otherwise permissive macrophages from susceptible A/J mice and induced production of the proinflammatory cytokines interleukin 1 and tumor necrosis factor alpha. Activation of the macrophages was similar to that which occurred after stimulation with more conventional lipid A from other bacteria such as salmonellae. A purified fraction A3 preparation from the Pseudomonas lipid A, which lacked only 1 mol of amide-linked fatty acid, in comparison with another fraction (A2), which contained the fatty acid, also markedly activated the usually permissive macrophages from susceptible A/J mice to resist growth of the legionellae. The fraction A3 also induced both interleukin and tumor necrosis factor alpha. These results show that this novel lipid A from P. vesicularis can activate macrophages to resist infection with an opportunistic bacterium in a manner similar to that induced by conventional enterobacterial lipid A and that the hydrophobic portion of this Pseudomonas molecule may have an important role in activation of macrophages.
机译：A / J小鼠的腹膜分泌物巨噬细胞被水泡假单胞菌纯化的脂质A制剂激活，其中含有2,3-二氨基-2,3-二脱氧-D-葡萄糖二糖磷酸单酯作为脂质A骨架，限制了嗜肺军团菌的生长，一种细胞内机会细菌，它容易在易感A / J小鼠的原本允许的巨噬细胞中生长，并诱导促炎性细胞因子白介素1和肿瘤坏死因子α的产生。巨噬细胞的活化类似于用其他细菌如沙门氏菌的更常规脂质A刺激后发生的活化。与仅含有1摩尔酰胺连接脂肪酸的假单胞菌脂质A纯化的A3馏分制剂相比，与含有该脂肪酸的另一馏分（A2）相比，它也显着激活了易感A / J中通常允许的巨噬细胞小鼠抵抗军团菌的生长。组分A3还诱导白介素和肿瘤坏死因子α。这些结果表明，这种来自水疱假单胞菌的新型脂质A可以激活巨噬细胞以抵抗机会细菌的感染，其方式类似于常规肠杆菌脂质A诱导的方式，并且该假单胞菌分子的疏水部分可能在活化中起重要作用。巨噬细胞。

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