Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection

Malcolm S. Duthie; Maria Kahn; Maria White; Raj P. Kapur; Stuart J. Kahn

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Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection

机译：CD1d抗原呈递和白细胞介素12都需要在克鲁斯锥虫感染期间激活天然杀伤性T细胞

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Mechanisms of natural killer T (NKT)-cell activation remain unclear. Here, we report that during Trypanosoma cruzi infection, interleukin-12 (IL-12) deficiency or anti-CD1d antibody treatment prevents normal activation. The required IL-12 arises independently of MyD88. The data support a model of normal NKT-cell activation that requires IL-12 and TCR stimulation.

机译：天然杀伤T（NKT）细胞激活的机制仍不清楚。在这里，我们报道在克鲁姆氏锥虫感染期间，白介素12（IL-12）缺乏或抗CD1d抗体治疗会阻止正常激活。所需的IL-12与MyD88无关。数据支持需要IL-12和TCR刺激的正常NKT细胞激活模型。

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《Infection and immunity》 |2005年第3期|共5页
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Malcolm S. Duthie; Maria Kahn; Maria White; Raj P. Kapur; Stuart J. Kahn;
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中图分类医学免疫学;
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1. Lipid-Antigen Presentation by CD1d + B Cells Is Essential for the Maintenance of Invariant Natural Killer T Cells [J] . BosmaA., Abdel-GadirA., IsenbergD.A., Immunity . 2012,第3期

机译：CD1d + B细胞的脂质抗原呈递对于维持不变的自然杀伤性T细胞至关重要
2. Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells. [J] . Enrico Girardi, Dirk M Zajonc Immunological reviews. . 2012,第Null期

机译：CD1d呈递脂质抗原并被自然杀伤性T细胞识别的分子基础。
3. Impairment in natural killer cells editing of immature dendritic cells by infection with a virulent trypanosoma cruzi population [J] . BatallaE.I., PinoMartínezA.M., PonciniC.V., Journal of innate immunity . 2013,第5期

机译：感染克鲁斯锥虫的自然杀伤细胞对未成熟树突状细胞编辑的损害
4. Trypanosoma cruzi infection induces nitric oxide production and S-nitrosylation of cellular FLIP in host cells [C] . Shimada J., Hatabu T. International Congress of Parasitology . 2010

机译：胰蛋白酶瘤Cruzi感染诱导宿主细胞中细胞翻转的一氧化氮产生和S-亚硝基化
5. The Role of Antigen Receptor Signaling in Activation and Development of invariant Natural Killer T Cells. [D] . Holzapfel, Keli Lee. 2014

机译：抗原受体信号传导在不变的天然杀伤性T细胞活化和发育中的作用。
6. Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection [O] . Malcolm S. Duthie, Maria Kahn, Maria White, 2005

机译：CD1d抗原呈递和白细胞介素12都需要在克鲁斯锥虫感染期间激活自然杀伤性T细胞
7. Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection [O] . Duthie, Malcolm S., Kahn, Maria, White, Maria, 2005

机译：CD1d抗原呈递和白细胞介素12都需要在克鲁斯锥虫感染期间激活自然杀伤性T细胞

Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection

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