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首页> 外文期刊>Infection and immunity >Mycobacterium tuberculosis with Disruption in Genes Encoding the Phosphate Binding Proteins PstS1 and PstS2 Is Deficient in Phosphate Uptake and Demonstrates Reduced In Vivo Virulence
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Mycobacterium tuberculosis with Disruption in Genes Encoding the Phosphate Binding Proteins PstS1 and PstS2 Is Deficient in Phosphate Uptake and Demonstrates Reduced In Vivo Virulence

机译:结核分枝杆菌在编码磷酸盐结合蛋白PstS1和PstS2的基因中具有破坏性,因此磷酸盐吸收不足并显示体内毒力降低

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摘要

By measuring phosphate uptake by Mycobacterium tuberculosis strains with the pstS1 and pstS2 genes genetically inactivated, we showed that these pstS genes encode high-affinity phosphate binding proteins. In a mouse infection model, both mutants were attenuated in virulence, suggesting that M. tuberculosis encounters limiting phosphate concentrations during its intracellular life span.
机译:通过测量具有基因灭活的 pstS1 pstS2 基因的结核分枝杆菌菌株的磷酸盐吸收,我们证明了这些 pstS 基因编码高亲和力的磷酸盐结合蛋白。在小鼠感染模型中,两个突变体的毒力均减弱,表明 M。结核病在其细胞内寿命期间会遇到极限磷酸盐浓度。

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