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Hyperinfectivity of Human-Passaged Vibrio cholerae Can Be Modeled by Growth in the Infant Mouse

机译:可以通过婴儿小鼠的生长来模拟人传代霍乱弧菌的超感染性

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It has previously been shown that passage of Vibrio cholerae through the human intestine imparts a transient hyperinfectious phenotype that may contribute to the epidemic spread of cholera. The mechanism underlying this human-passaged hyperinfectivity is incompletely understood, in part due to inherent difficulties in recovering and studying organisms that are freshly passed in human stool. Here, we demonstrate that passage of V. cholerae through the infant mouse intestine leads to an equivalent degree of hyperinfectivity as passage through the human host. We have used this infant mouse model of host-passaged hyperinfectivity to characterize the timing and the anatomic location of the competitive advantage of mouse-passaged V. cholerae as well as the contribution of three type IV pili to the phenotype.
机译:先前已证明霍乱弧菌通过人的肠道会产生短暂的高感染性表型,可能导致霍乱的流行。这种人为传播的过度感染的潜在机制尚未完全理解,部分原因是在回收和研究人粪便中新近传播的生物时存在固有的困难。在这里,我们演示了 V的通过。霍乱弧菌通过小鼠小肠会导致与人类宿主相同程度的高感染性。我们已经使用了宿主传播的高感染性的这种婴儿小鼠模型来表征小鼠传播的 V竞争优势的时机和解剖位置。霍乱以及三种IV型菌毛对表型的贡献

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