Skin Test Performed with Highly Purified Mycobacterium tuberculosis Recombinant Protein Triggers Tuberculin Shock in Infected Guinea Pigs

Stephen T. Reece; Nicole Stride; Pamela Ovendale; Steven G. Reed; Antonio Campos-Neto

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Skin Test Performed with Highly Purified Mycobacterium tuberculosis Recombinant Protein Triggers Tuberculin Shock in Infected Guinea Pigs

机译：用高纯度结核分枝杆菌重组蛋白进行的皮肤试验触发了感染豚鼠的结核菌素休克

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Tuberculin shock due to inoculation of Mycobacterium tuberculosis antigens in patients with tuberculosis is a serious syndrome originally described over 100 years ago by Robert Koch. Here, we present experimental evidence that a single M. tuberculosis recombinant protein, CFP-10, triggers this syndrome. Intradermal inoculation of CFP-10 elicits in M. tuberculosis-infected mice high levels of serum tumor necrosis factor alpha and causes tuberculin shock in infected guinea pigs characterized by hypothermia and death within 6 to 48 h after the antigen inoculation. Autopsies of these animals revealed intense polycythemia and hemorrhagic patches in the lung parenchyma, a pathological observation consistent with tuberculin shock. These results point to the possible occurrence of tuberculin shock in sensitive individuals inoculated with highly purified M. tuberculosis recombinant proteins as vaccine candidates or skin test reagents.

机译：结核病患者接种结核分枝杆菌抗原导致的结核菌素休克是一种严重的综合症，最初由罗伯特·科赫（Robert Koch）于100多年前描述。在这里，我们提供单个 M的实验证据。结核病重组蛋白CFP-10触发了这种综合征。在 M中引起CFP-10的皮内接种。感染结核杆菌的小鼠血清中的肿瘤坏死因子α含量高，并在抗原接种后6至48小时内使受感染豚鼠的结核菌素休克以体温过低和死亡为特征。这些动物的尸检显示肺实质中存在严重的红细胞增多症和出血斑块，这是与结核菌素休克相一致的病理观察。这些结果表明，在接种高纯度 M的敏感个体中，结核菌素休克可能发生。结核重组蛋白作为候选疫苗或皮肤测试试剂。 展开▼

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《Infection and immunity》 |2005年第6期|共6页

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Stephen T. Reece; Nicole Stride; Pamela Ovendale; Steven G. Reed; Antonio Campos-Neto;
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中图分类医学免疫学;

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1. Skin Test Performed with Highly Purified Mycobacterium tuberculosis Recombinant Protein Triggers Tuberculin Shock in Infected Guinea Pigs [J] . Stephen T. Reece, Nicole Stride, Pamela Ovendale, Infection and immunity . 2005,第6期

机译：用高纯度结核分枝杆菌重组蛋白进行的皮肤试验触发了感染豚鼠的结核菌素休克

2. Towards Improvement of Tuberculin Skin Test: Five Potential Antigenic Proteinselicited in vitro Specific Immune Reaction Against Mycobacterium tuberculous Species Using Sensitized Guinea Pig Models [J] . Amr M. Mohamed, Ahmed M. Ashshi, Basem A. Refaat, Journal of animal and veterinary advances . 2015,第10期

机译：改善结核菌素皮肤试验：使用致敏的豚鼠模型对结核分枝杆菌进行五种潜在的抗原蛋白体外特异性免疫反应

3. Tuberculin response in guinea pigs with recombinant proteins cocktail prepared from Indian strain of Mycobacterium bovis (3/86 Rv) [J] . Ramane Sangram Pandit, Verma Rishendra, Mondal Tista, Indian Journal of Experimental Biology . 2018,第9期

机译：豚鼠的结核菌反应与重组蛋白质鸡尾酒中的印度肉杆菌（3/86 RV）制备

4. LC-MS Analysis of Hydrophilic Metabolites in Guinea Pig Lungs Infected with Mycobacterium tuberculosis [C] . Justin Searcy, Gavin Ryan, Courtney Hastings, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：豚鼠肺部分枝杆菌病患者亲水代谢物的LC-MS分析

5. Effects of reminder telephone calls on return rates for tuberculin purified protein derivative skin test reading in a multicultural urban obstetrics clinic [D] . Edmondson-Holt, Ardis Helaine 2006

机译：提醒电话对多文化城市产科诊所结核菌素纯化蛋白衍生物皮肤试验读数返回率的影响

6. Skin Test Performed with Highly Purified Mycobacterium tuberculosis Recombinant Protein Triggers Tuberculin Shock in Infected Guinea Pigs [O] . Stephen T. Reece, Nicole Stride, Pamela Ovendale, 2005

机译：用高纯度结核分枝杆菌重组蛋白进行的皮肤试验触发了感染豚鼠的结核菌素休克

7. Skin Test Performed with Highly Purified Mycobacterium tuberculosis Recombinant Protein Triggers Tuberculin Shock in Infected Guinea Pigs [O] . Reece, Stephen T., Stride, Nicole, Ovendale, Pamela, 2005

机译：用高纯度结核分枝杆菌重组蛋白进行的皮肤试验触发了感染豚鼠的结核菌素休克

1. 结核菌素皮肤试验和γ干扰素释放试验检测917名医务人员结核分枝杆菌感染一致性的比较分析 [J] . 耿梦杰 ,宋渝丹 ,熊勇超 . 中国防痨杂志 . 2014,第002期

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3. 重组结核分枝杆菌1600O蛋白抗原(rPA16)豚鼠皮肤试验效果的研究 [J] . 熊志红 ,庄玉辉 ,张晓刚 . 中国现代医学杂志 . 2000,第012期

4. 干扰素γ释放试验联合结核菌素皮肤试验在眼内结核和潜伏性结核感染诊断中的应用价值 [J] . 张彦坤 ,白洪忠 ,关艳 . 中国医师进修杂志 . 2019,第009期

5. γ干扰素释放试验与结核菌素皮肤试验应用于人群结核潜伏性感染诊断的比较 [J] . 丁晓艳 ,陆伟 ,刘巧 . 江苏预防医学 . 2018,第003期

6. 干扰素γ释放试验和结核菌素皮肤试验在儿童结核病和潜伏结核感染诊断和筛查中的应用研究——Meta分析 [C] . 孙琳 ,刘芳 ,申阿东 . 中华医学会结核病学分会2011年学术会议 . 2011

7. 融合蛋白亚单位疫苗对结核分枝杆菌感染豚鼠和小鼠免疫治疗效果的初步评价 [A] . 许承明 . 2014

1. 一种饮水感染结核分枝杆菌豚鼠模型的建立方法 [P] . 中国专利： CN105010239A . 2015-11-04

2. Isolated dna molecule isolated protein or polypeptide process to vaccinate mammals against mycobacterium tuberculosis infection recombinant dna expression system vaccine host to prevent infection and mammalian disease by mycobacterium tuberculosis process to vaccinate mammals isolated antibody or binding moiety same process and composition to passively imminate mammals infected with mycobacterium tuberculosis processes to detect mycobacterium tuber [P] . 外国专利： BR9607406A . 1998-07-07

机译：分离的dna分子分离的蛋白质或多肽过程，用于对哺乳动物进行结核分枝杆菌感染的疫苗接种重组dna表达系统疫苗宿主，用于预防分枝杆菌的感染和哺乳动物疾病，以对哺乳动物分离的抗体或结合部分进行疫苗接种，相同的过程和组成，以被动地模仿被分枝杆菌感染的哺乳动物检测结核分枝杆菌的结核病过程

3. Method of infection of guinea pigs in the study of biological properties of Mycobacterium tuberculosis [P] . 外国专利： RU2005132868A . 2007-04-27

机译：结核分枝杆菌生物学特性研究中豚鼠的感染方法

4. METHOD FOR INFECTING GUINEA PIGS AT STUDYING BIOLOGICAL PROPERTIES OF TUBERCULOSIS MYCOBACTERIA [P] . 外国专利： RU2314572C2 . 2008-01-10

机译：研究豚鼠结核分枝杆菌生物学特性的感染豚鼠的方法

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Skin Test Performed with Highly Purified Mycobacterium tuberculosis Recombinant Protein Triggers Tuberculin Shock in Infected Guinea Pigs

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