Localization of the Hypothetical Protein Cpn0797 in the Cytoplasm of Chlamydia pneumoniae-Infected Host Cells

Feng Dong; Rhonda Flores; Ding Chen; Jianhua Luo; Youmin Zhong; Zhongming Wu; Guangming Zhong

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Localization of the Hypothetical Protein Cpn0797 in the Cytoplasm of Chlamydia pneumoniae-Infected Host Cells

机译：假设蛋白Cpn0797在肺炎衣原体感染宿主细胞的细胞质中的定位

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Using antibodies raised with chlamydial fusion proteins, we have localized a protein encoded by the hypothetical open reading frame Cpn0797 in the cytoplasm of Chlamydia pneumoniae-infected host cells. The anti-Cpn0797 antibodies specifically recognized Cpn0797 protein without cross-reacting with either CPAFcp or Cpn0796, the only two proteins known to be secreted into the host cell cytosol by C. pneumoniae organisms. Thus, Cpn0797 represents the third C. pneumoniae protein secreted into the host cell cytosol experimentally identified so far.

机译：使用衣原体融合蛋白产生的抗体，我们将由假设的开放阅读框Cpn0797编码的蛋白定位在感染了肺炎衣原体的宿主细胞的细胞质中。抗Cpn0797抗体可特异性识别Cpn0797蛋白，而不会与CPAFcp或Cpn0796交叉反应，CPAFcp或Cpn0796是已知唯一被 C分泌到宿主细胞胞质溶胶中的两种蛋白质。肺炎生物。因此，Cpn0797代表第三个 C。到目前为止，实验上已鉴定出分泌到宿主细胞胞质溶胶中的肺炎蛋白。 展开▼

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《Infection and immunity》 |2006年第11期|共8页

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Feng Dong; Rhonda Flores; Ding Chen; Jianhua Luo; Youmin Zhong; Zhongming Wu; Guangming Zhong;
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中图分类医学免疫学;

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专利

1. Localization of Chlamydia trachomatis hypothetical protein CT311 in host cell cytoplasm [J] . Lei Lei, Qi Manli, Budrys Nicole, Microbial Pathogenesis . 2011,第3期

机译：沙眼衣原体假设蛋白CT311在宿主细胞质中的定位

2. Localization of the hypothetical protein Cpn0585 in the inclusion membrane of Chlamydia pneumoniae-infected cells [J] . Luo J, Jia T, Zhong Y, Microbial Pathogenesis . 2007,第2a3期

机译：假设蛋白Cpn0585在肺炎衣原体感染细胞的包膜中的定位

3. Chlamydia trachomatis Secretion of an Immunodominant Hypothetical Protein (CT795) into Host Cell Cytoplasm [J] . Manli Qi, Lei Lei, Siqi Gong, Journal of bacteriology . 2011,第10期

机译：沙眼衣原体向宿主细胞质中分泌免疫阳性假说蛋白（CT795）

4. Exploring the hypothetical protein complex-Scc1/CT663 in the type three secretion system of Chlamydia trachomatis [C] . Kyla M. Frohlich, Chau-Wen Chou, Li Shen American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：探索衣原体三种分泌系统的假设蛋白质复合体-CC1 / CT663

5. Herpes Simplex Virus glycoprotein D/host cell surface interaction stimulates Chlamydia trachomatis persistence via a novel pathway [D] . Vanover, Jennifer 2008

机译：单纯疱疹病毒糖蛋白D /宿主细胞表面相互作用通过新途径刺激沙眼衣原体持续存在

6. Localization of the Hypothetical Protein Cpn0797 in the Cytoplasm of Chlamydia pneumoniae-Infected Host Cells [O] . Feng Dong, Rhonda Flores, Ding Chen, 2006

机译：假设蛋白Cpn0797在肺炎衣原体感染宿主细胞的细胞质中的定位

7. Localization of the Hypothetical Protein Cpn0797 in the Cytoplasm of Chlamydia pneumoniae-Infected Host Cells [O] . Dong, Feng, Flores, Rhonda, Chen, Ding, 2006

机译：假设蛋白Cpn0797在肺炎衣原体感染宿主细胞的细胞质中的定位

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7. Neddylation修饰对蛋白质在细胞核与细胞质中定位影响的研究 [A] . 李少华 . 2020

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2. 用于生物治疗蛋白质产品中的宿主细胞蛋白质污染物的检测的SWATH^TM数据独立性采集技术 [P] . 中国专利： CN105209907B . 2019.08.16

3. Hmw protein of the isolated chlamydia species, isolated nucleic acid molecule, recombinant expression vector, transformed host cell, isolated recombinant protein or fragment or analog thereof, immunogenic composition, antigenic composition, processes to produce an immune response in an animal, anti- serum, antibodies, diagnostic reagent, to detect anti-chlamydia antibodies in a test sample, to detect the presence of chlamydia in a test sample, to prevent, treat or ameliorate a chlamydia-related disorder in a host in need of this treatment , and to determine the presence of nucleic acid encoding an hmw protein or a fragment or analog thereof in a sample, diagnostic kits to detect antibodies to chlamydia, and to determine the presence of nucleic acid encoding an hmw protein or fragment or analog thereof in a sample, vaccine composition, and pharmaceutical composition The [P] . 外国专利： BR9813841A . 2000-10-03

机译：分离的衣原体物种的Hmw蛋白，分离的核酸分子，重组表达载体，转化的宿主细胞，分离的重组蛋白或其片段或类似物，免疫原性组合物，抗原性组合物，在动物中产生免疫应答的过程，抗血清，抗体，诊断试剂，用于检测测试样品中的衣原体抗体，检测测试样品中的衣原体，预防，治疗或缓解需要此治疗的宿主中的衣原体相关疾病，并确定样品中是否存在编码hmw蛋白或其片段或类似物的核酸，诊断试剂盒以检测针对衣原体的抗体以及确定样品，疫苗组合物中是否存在编码hmw蛋白或其片段或类似物的核酸和药物成分

4. EXPRESSION OF RECOMBINANT PROTEINS IN PLASTIDS OF HIGHER PLANTS AND THE SECRETION OF PROTEIN INTO CYTOPLASM OF THE HOST CELL [P] . 外国专利： IN2008DE02689A . 2010-06-04

机译：重组蛋白在高等植物中的表达及蛋白在宿主细胞中的分泌

5. Anti-chlamydial activity of BPI (bactericidal/permeability increasing proteins) protein products against chlamydia infected host cells [P] . 外国专利： NZ334041A . 2000-10-27

机译：BPI（杀菌/通透性增强蛋白）蛋白产品对衣原体感染宿主细胞的抗衣原体活性

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Localization of the Hypothetical Protein Cpn0797 in the Cytoplasm of Chlamydia pneumoniae-Infected Host Cells

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