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首页> 外文期刊>Infection and immunity >Identification of Genes Encoding Two-Component Lantibiotic Production in Staphylococcus aureus C55 and Other Phage Group II S. aureus Strains and Demonstration of an Association with the Exfoliative Toxin B Gene
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Identification of Genes Encoding Two-Component Lantibiotic Production in Staphylococcus aureus C55 and Other Phage Group II S. aureus Strains and Demonstration of an Association with the Exfoliative Toxin B Gene

机译：金黄色葡萄球菌C55和其他噬菌体组II金黄色葡萄球菌菌株中编码两种成分羊毛硫抗生素生产的基因的鉴定和与脱落性毒素B基因的关联的证明

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摘要

The production of exfoliative toxin B (ET-B), but not ET-A, was shown to be specifically associated with production of a highly conserved two-component lantibiotic peptide system in phage group IIStaphylococcus aureus. Two previously studied but incompletely characterized S. aureus bacteriocins, staphylococcins C55 and BacR1, were found to be members of this lantibiotic system, and considerable homology was also found with the two-component Lactococcus lactis bacteriocin, lacticin 3147. sacαA and sacβA, the structural genes of the lantibiotics staphylococcins C55α and C55β and two putative lantibiotic processing genes, sacM1 and sacT, were localized together with the ET-B structural gene to a single 32-kb plasmid in strain C55. Irreversible loss of both ET-B and two-component lantibiotic production occurs during laboratory passage of ET-B-positive S. aureus strains, particularly at elevated temperatures.
机译：剥脱性毒素B（ET-B）的产生，而不是ET-A的产生，与噬菌体II 金黄色葡萄球菌中高度保守的两组分羊毛硫抗生素肽系统的产生特别相关。两个以前研究过但特征不完全的 S。发现金黄色葡萄球菌，葡萄球菌C55和BacR1是该羊毛硫抗生素系统的成员，并且还与两成分的乳酸乳球菌（Lactococcus lactis）细菌蓝霉素3147有相当的同源性。 sacαA和sacβA，羊毛硫抗生素葡萄球菌C55α和C55β的结构基因以及两个假定的羊毛硫抗生素加工基因 sacM1 和 sacT ，将其与ET-B结构基因一起定位于菌株C55中的单个32kb质粒。 ET-B阳性 S的实验室通过期间，ET-B和两组分羊毛硫抗生素的产生均不可逆转地损失。金黄色葡萄球菌菌株，尤其是在高温下。

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