...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >T-Cell Responses to Immunodominant LACK Antigen Do Not Play a Critical Role in Determining Susceptibility of BALB/c Mice toLeishmania mexicana
【24h】

T-Cell Responses to Immunodominant LACK Antigen Do Not Play a Critical Role in Determining Susceptibility of BALB/c Mice toLeishmania mexicana

机译：T细胞对免疫性LACK抗原的应答在确定BALB / c小鼠对墨西哥利什曼原虫的敏感性中不发挥关键作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although BALB/c mice develop lesions when infected withLeishmania mexicana, the mechanisms which are responsible for susceptibility to this parasite have not been elucidated. In contrast, susceptibility of BALB/c mice to Leishmania majorhas been shown to depend on the early production of interleukin-4 (IL-4) by T cells which react to the parasitic LACK antigen. Here, we demonstrate that the lesions induced by L. mexicana are delayed compared to those induced by L. major but rapidly develop at later time points. Interestingly, while LACK-tolerant BALB/c-derived IE-LACK transgenic mice were resistant to L. major, they were susceptible to L. mexicana and developed lesions similar to those observed in wild-type BALB/c mice. The latter result was observed despite the fact that (i) LACK was expressed by L. mexicana, (ii) splenocytes from BALB/c mice were able to stimulate LACK-specific T-cell hybridoma cells when incubated with live L. mexicana promastigotes, and (iii) LACK-specific T cells contributed to IL-4 production in L. mexicana-infected BALB/c mice. Thus, in contrast to what was observed for L. major-infected mice, LACK-specific T cells do not play a critical role in determining susceptibility to L. mexicana. Although BALB/c mice are susceptible to both L. major and L. mexicana, the mechanisms which are responsible for susceptibility to these parasites are likely to be different.
机译：尽管BALB / c小鼠在感染利什曼原虫后会出现损伤，但尚未阐明引起该寄生虫易感性的机制。相比之下，业已证明，BALB / c小鼠对大利什曼原虫的易感性取决于与寄生LACK抗原反应的T细胞早期产生白介素4（IL-4）。在这里，我们证明了 L诱导的病变。与 L诱导的墨西哥相比，墨西哥的延迟。专业，但在随后的时间点迅速发展。有趣的是，虽然耐LACK的BALB / c衍生的IE-LACK转基因小鼠对L耐药。 ，他们容易感染 L。 mexicana 并发展出与野生型BALB / c小鼠相似的病变。尽管（i）LACK由 L表示，但观察到了后者的结果。 mexicana ，（ii）来自BALB / c小鼠的脾细胞在与活的 L孵育后能够刺激LACK特异性T细胞杂交瘤细胞。 mexicana 前鞭毛体和（iii）LACK特异性T细胞促成 L中IL-4的产生。墨西哥感染的BALB / c小鼠。因此，与 L观察到的相反。感染大型的小鼠中，LACK特异性T细胞在确定对 L的易感性中不发挥关键作用。墨西哥。尽管BALB / c小鼠对两种 L均易感。 major 和 L。墨西哥，导致这些寄生虫易感性的机制可能有所不同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号