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首页> 外文期刊>Infection and immunity >Old Mice Express a Transient Early Resistance to Pulmonary Tuberculosis That Is Mediated by CD8 T Cells
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Old Mice Express a Transient Early Resistance to Pulmonary Tuberculosis That Is Mediated by CD8 T Cells

机译：老小鼠对CD8 T细胞介导的肺结核表现出短暂的早期耐药性

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During the natural aging process the immune system undergoes many alterations. In particular, both the CD4 and CD8 T-cell compartments become compromised, and these changes have serious implications for the capacity of the elderly to control infection. As a result, the elderly are more susceptible to many infectious diseases, including primary infection and reactivation of latent infections. In this study we addressed the capacity of old mice to control an infection with Mycobacterium tuberculosis and to characterize the mechanism by which old mice, paradoxically, can express a transient early resistance to infection. This resistance was shown to be associated with the presence of CD8 T cells within the lungs that were capable of secreting gamma interferon, as illustrated by the demonstration that early resistance was lost in aged CD8 gene-disrupted mice. These studies therefore show that, despite a documented decline in general CD8 T-cell responsiveness in the elderly, a subset of CD8 T cells is an important early mediator of protection in the lungs of old mice that have been infected with M. tuberculosis.
机译：在自然衰老过程中，免疫系统会发生许多变化。特别是，CD4和CD8 T细胞区室都受到损害，这些变化对老年人控制感染的能力产生了严重影响。结果，老年人更容易感染许多传染病，包括原发感染和潜伏感染的再激活。在这项研究中，我们探讨了老年小鼠控制结核分枝杆菌感染的能力，并描述了老年小鼠自相矛盾地表达对感染的短暂抗药性的机制。已证明这种抗性与能够分泌γ干扰素的肺中CD8 T细胞的存在有关，这表明在衰老的CD8基因破坏的小鼠中早期抗性丧失了。因此，这些研究表明，尽管有文献报道老年人中一般的CD8 T细胞反应性下降，但CD8 T细胞的一部分是在感染了 M的老年小鼠的肺中重要的早期保护介质。结核病。

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