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首页> 外文期刊>Infection and immunity >Dissemination of Mycobacterium tuberculosis Is Influenced by Host Factors and Precedes the Initiation of T-Cell Immunity
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Dissemination of Mycobacterium tuberculosis Is Influenced by Host Factors and Precedes the Initiation of T-Cell Immunity

机译：结核分枝杆菌的传播受到宿主因素的影响，并且优先于T细胞免疫的启动

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We report that dissemination of Mycobacterium tuberculosis in the mouse is under host control and precedes the initiation of T-cell immunity. Nine to eleven days after aerosol inoculation, M. tuberculosis disseminates to the pulmonary lymph nodes (LN), where M. tuberculosis-specific T cells are detected 2 to 3 days thereafter. This indicates that the initial spread of bacteria occurs via lymphatic drainage and that the acquired T-cell immune response is generated in the draining LN. Dissemination to peripheral sites, such as the spleen and the liver, occurs 11 to 14 days postinfection and is followed by the appearance of M. tuberculosis-specific T cells in the lung and the spleen. In all cases studied, dissemination to the LN or the spleen preceded activation of M. tuberculosis-specific T cells in that organ. Interestingly, bacteria disseminate earlier from the lungs of resistant C57BL/6 mice than from the lungs of susceptible C3H mice, and consequently, C57BL/6 mice generate an immune response to M. tuberculosis sooner than C3H mice generate an immune response. Thus, instead of spreading infection, early dissemination of M. tuberculosis may aid in the initiation of an appropriate and timely immune response. We hypothesize that this early initiation of immunity following inoculation with M. tuberculosis may contribute to the superior resistance of C57BL/6 mice.
机译：我们报道，结核分枝杆菌在小鼠中的传播处于宿主控制之下，并且先于T细胞免疫开始。气雾剂接种后9到11天，。结核传播到肺淋巴结（LN），其中 M。此后2至3天检测到结核特异性T细胞。这表明细菌的初始传播是通过淋巴引流发生的，并且获得的T细胞免疫反应是在引流LN中产生的。在感染后11至14天，扩散到周围部位，例如脾脏和肝脏，并随后出现 M。肺和脾中结核特异性T细胞在所有研究的病例中，在激活 M之前，先向LN或脾脏扩散。该器官中的结核特异性T细胞有趣的是，细菌从抗性C57BL / 6小鼠的肺中传播的速度比从易感C3H小鼠的肺中传播的速度快，因此，C57BL / 6小鼠产生了针对 M的免疫反应。结核病比C3H小鼠更早产生免疫反应。因此，早期传播 M而不是传播感染。结核可能有助于适当和及时的免疫反应的启动。我们假设接种 M后免疫的这种早期启动。结核可能是导致C57BL / 6小鼠耐药的原因。

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