Chlamydia pneumoniae Secretion of a Protease-Like Activity Factor for Degrading Host Cell Transcription Factors Is Required for Major Histocompatibility Complex Antigen Expression

Peiyi Fan; Feng Dong; Yanqing Huang; Guangming Zhong

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Chlamydia pneumoniae Secretion of a Protease-Like Activity Factor for Degrading Host Cell Transcription Factors Is Required for Major Histocompatibility Complex Antigen Expression

机译：主要组织相容性复合物抗原表达需要蛋白酶样活性因子降解宿主细胞转录因子的肺炎衣原体分泌

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Chlamydia pneumoniae is a causative agent for many respiratory infections and has been associated with cardiovascular diseases in humans. The pathogenicity of C. pneumoniae is thought to depend on its ability to cause persistent infection and to evade host defense. Genome sequence analysis indicates that C. pneumoniae encodes a homologue of a chlamydial protease-like activity factor from C. trachomatis (CPAFct). We designated the C. pneumoniae homologue as CPAFcp. Recombinant CPAFcp was produced and found to degrade RFX5, a host transcription factor required for major histocompatibility complex (MHC) antigen expression. The degradation was inhibitable by lactacystin, an irreversible proteasome inhibitor. Furthermore, CPAFcp was secreted into host cytosol by C. pneumoniae organisms. Depletion of the C. pneumoniae-secreted CPAFcp with specific antibodies completely ablated the RFX5 degradation activity in the infected cells, suggesting that CPAFcp is necessary for the degradation of host transcription factors required for MHC antigen expression during C. pneumoniae infection. These observations have revealed a unique molecular mechanism for C. pneumoniae to evade host adaptive immunity that may aid in its persistence.

机译：肺炎衣原体是许多呼吸道感染的病原体，与人类的心血管疾病有关。 C的致病性。肺炎被认为取决于其引起持续感染和逃避宿主防御的能力。基因组序列分析表明 C。肺炎编码 C的衣原体蛋白酶样活性因子的同源物。沙眼（CPAFct）。我们指定了 C。肺炎链球菌的CPAFcp同系物。产生了重组CPAFcp，并发现其降解RFX5，RFX5是主要组织相容性复合体（MHC）抗原表达所需的宿主转录因子。该降解可被不可逆的蛋白酶体抑制剂乳胞素抑制。此外，CPAFcp被 C分泌到宿主细胞质中。肺炎生物。 C的耗竭。肺炎球菌分泌的CPAFcp与特异性抗体完全消除了感染细胞中RFX5的降解活性，这表明CPAFcp对于降解在 C期间MHC抗原表达所需的宿主转录因子是必需的。肺炎感染。这些观察结果揭示了 C的独特分子机制。肺炎逃避宿主的适应性免疫，可能有助于其持久性。 展开▼

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《Infection and immunity》 |2002年第1期|共6页

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Peiyi Fan; Feng Dong; Yanqing Huang; Guangming Zhong;
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中图分类医学免疫学;

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1. Chlamydia pneumoniae Secretion of a Protease-Like Activity Factor for Degrading Host Cell Transcription Factors Is Required for Major Histocompatibility Complex Antigen Expression [J] . Peiyi Fan, Feng Dong, Yanqing Huang, Infection and immunity . 2002,第1期

机译：主要组织相容性复合物抗原表达需要蛋白酶样活性因子降解宿主细胞转录因子的肺炎衣原体分泌

2. Degradation of Transcription Factor Rfx5 during the Inhibition of Both Constitutive and Interferon γ–Inducible Major Histocompatibility Complex Class I Expression in Chlamydia-Infected Cells [J] . Guangming Zhong, Li Liu, Tao Fan, The Journal of Experomental Medicine . 2000,第9期

机译：衣原体感染细胞中本构和干扰素γ诱导的主要组织相容性复合体I类表达的抑制过程中转录因子Rfx5的降解。

3. The host adherens junction molecule nectin-1 is degraded by chlamydial protease-like activity factor (CPAF) in Chlamydia trachomatis-infected genital epithelial cells. [J] . Sun J, Schoborg RV Microbes and infection . 2009,第10a11期

机译：在沙眼衣原体感染的生殖器上皮细胞中，宿主粘附的连接分子nectin-1被衣原体蛋白酶样活性因子（CPAF）降解。

4. Expression of GATA-3, c-Maf and Helios transcription factor mRNA by CD4 T cells responding to Th2 antigen in vivo [C] . Serre K., Mohr E., Toellner K.M., European Congress of Immunology . 2009

机译：CD4 T细胞在体内响应Th2抗原的CD4 T细胞表达GATA-3，C-MAF和HELIOS转录因子mRNA

5. Increased density of class I major histocompatibility complex antigens and decreased density of T-cell differentiation antigens in the early stages of T-cell activation [D] . 松井良樹 1988

机译：在T细胞活化的早期，I类主要组织相容性复合抗原的密度增加，而T细胞分化抗原的密度降低

6. Chlamydia pneumoniae Secretion of a Protease-Like Activity Factor for Degrading Host Cell Transcription Factors Is Required for Major Histocompatibility Complex Antigen Expression [O] . Peiyi Fan, Feng Dong, Yanqing Huang, 2002

机译：主要组织相容性复合物抗原表达需要蛋白酶样活性因子降解宿主细胞转录因子的肺炎衣原体分泌

7. Chlamydia pneumoniae Secretion of a Protease-Like Activity Factor for Degrading Host Cell Transcription Factors Is Required for Major Histocompatibility Complex Antigen Expression [O] . Fan, Peiyi, Dong, Feng, Huang, Yanqing, 2002

机译：主要组织相容性复合物抗原表达需要蛋白酶样活性因子降解宿主细胞转录因子的肺炎衣原体分泌

1. 肺炎衣原体蛋白酶样活性因子在急性感染期的表达和分泌 [J] . 牛玉宏 ,董峰 ,史剑慧 . 中华微生物学和免疫学杂志 . 2004,第004期

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3. 大肠癌组织组织相容性复合物Ⅰ、Ⅱ类抗原表达及其与转移的关系 [J] . 程宝泉 ,上官红 ,乔立洪 . 中华消化杂志 . 2002,第008期

4. 同种移植大鼠心脏Ⅱ类主要组织相容性抗原表达及其机制探讨 [J] . 陈振光 ,孙培吾 ,项鹏 . 中华心血管病杂志 . 2003,第002期

5. 环孢霉素A对培养的人角朊细胞主要组织相容性抗原表达的影响 [J] . 汤朝武 ,陈璧 . 第四军医大学学报 . 1999,第005期

6. 欧亚猞猁主要组织相容性复合物遗传多样性研究 [C] . 汪小方 ,韦鹍 ,张志和 . 野生动物生态与资源保护第五届全国学术研讨会 . 2009

7. 通过将猪主要组织相容性复合物SLA-1替换成人主要组织相容性复合物HLA-A建立用于异种移植的猪细胞系的研究 [A] . 曾晔临 . 2015

1. 使用正痘病毒主要组织相容性复合物（MHC）I类样蛋白（OMCP）和肿瘤特异性结合伴侣的双特异性融合蛋白 [P] . 中国专利： CN114072416A . 2022-02-18

2. 表达人源化主要组织相容性复合物的小鼠 [P] . 中国专利： CN110192541B . 2022.02.18

3. Isolated antigen-binding protein, nucleic acid molecule, vector, host cell, methods for preparing antigen-binding protein, for treating or preventing a condition, for inhibiting granulocyte macrophage colony stimulating factor binding to the extracellular portion of granulocyte macrophage colony stimulating factor receptor, and to inhibit granulocyte macrophage colony stimulating factor activity, and, pharmaceutical composition [P] . 外国专利： BRPI0817007A2 . 2015-03-24

机译：分离的抗原结合蛋白，核酸分子，载体，宿主细胞，抗原结合蛋白的制备方法，治疗或预防病症，抑制粒细胞巨噬细胞集落刺激因子结合至粒细胞巨噬细胞集落刺激因子受体的细胞外部分的方法，和抑制粒细胞巨噬细胞集落刺激因子活性，以及，药物组合物

4. isolated polypetide, composition, recombinant host cell, methods for producing the polypetide, a polypetide having cellulolytic enhancer activity, a precursor cell mutant, a protein and a fermentation product, transgenic plant, plant part or plant cell, double stranded inhibitor (rsrna), and methods for inhibiting expression of a polypeptide having cellulolytic enhancer activity in a cell, degrading or converting an isolated polypeptide, composition, recombinant host cell, methods for producing the polypetide, a polypetide having activity cellulolytic enhancer, a precursor cell mutant, a protein and a fermentation product, a transgenic plant, a plant part or a plant cell, a double stranded inhibitor (dsrna) molecule, and methods for inhibiting expression of a polypeptide having cellulolytic enhancer activity in a cell, degrade or convert r a cellulosic material and ferment a cellulosic material. [P] . 外国专利： BR112012006032A2 . 2015-09-08

机译：分离的多肽，组合物，重组宿主细胞，多肽的生产方法，具有纤维素分解增强活性的多肽，前体细胞突变体，蛋白质和发酵产物，转基因植物，植物部分或植物细胞，双链抑制剂（rsrna），抑制细胞中具有纤维素分解增强子活性的多肽的表达的方法和方法，降解或转化分离的多肽，组合物，重组宿主细胞，生产多肽的方法，具有纤维素分解增强子活性的多肽，前体细胞突变体，蛋白质和发酵产物，转基因植物，植物部分或植物细胞，双链抑制剂（dsrna）分子，以及抑制具有纤维素分解增强活性的多肽在细胞中表达，降解或转化纤维素物质并发酵的方法纤维素材料。

5. Hmw protein of the isolated chlamydia species, isolated nucleic acid molecule, recombinant expression vector, transformed host cell, isolated recombinant protein or fragment or analog thereof, immunogenic composition, antigenic composition, processes to produce an immune response in an animal, anti- serum, antibodies, diagnostic reagent, to detect anti-chlamydia antibodies in a test sample, to detect the presence of chlamydia in a test sample, to prevent, treat or ameliorate a chlamydia-related disorder in a host in need of this treatment , and to determine the presence of nucleic acid encoding an hmw protein or a fragment or analog thereof in a sample, diagnostic kits to detect antibodies to chlamydia, and to determine the presence of nucleic acid encoding an hmw protein or fragment or analog thereof in a sample, vaccine composition, and pharmaceutical composition The [P] . 外国专利： BR9813841A . 2000-10-03

机译：分离的衣原体物种的Hmw蛋白，分离的核酸分子，重组表达载体，转化的宿主细胞，分离的重组蛋白或其片段或类似物，免疫原性组合物，抗原性组合物，在动物中产生免疫应答的过程，抗血清，抗体，诊断试剂，用于检测测试样品中的衣原体抗体，检测测试样品中的衣原体，预防，治疗或缓解需要此治疗的宿主中的衣原体相关疾病，并确定样品中是否存在编码hmw蛋白或其片段或类似物的核酸，诊断试剂盒以检测针对衣原体的抗体以及确定样品，疫苗组合物中是否存在编码hmw蛋白或其片段或类似物的核酸和药物成分

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Chlamydia pneumoniae Secretion of a Protease-Like Activity Factor for Degrading Host Cell Transcription Factors Is Required for Major Histocompatibility Complex Antigen Expression

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