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首页> 外文期刊>Infection and immunity >Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection
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Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection

机译：食蟹猕猴的实验性结核分枝杆菌感染非常类似于人类结核分枝杆菌感染的各种表现

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摘要

Nonhuman primates were used to develop an animal model that closely mimics human Mycobacterium tuberculosis infection. Cynomolgus macaques were infected with low doses of virulent M. tuberculosis via bronchoscopic instillation into the lung. All monkeys were successfully infected, based on tuberculin skin test conversion and peripheral immune responses to M. tuberculosis antigens. Progression of infection in the 17 monkeys studied was variable. Active-chronic infection, observed in 50 to 60% of monkeys, was characterized by clear signs of infection or disease on serial thoracic radiographs and in other tests and was typified by eventual progression to advanced disease. Approximately 40% of monkeys did not progress to disease in the 15 to 20 months of study, although they were clearly infected initially. These monkeys had clinical characteristics of latent tuberculosis in humans. Low-dose infection of cynomolgus macaques appears to represent the full spectrum of human M. tuberculosis infection and will be an excellent model for the study of pathogenesis and immunology of this infection. In addition, this model will provide an opportunity to study the latent M. tuberculosis infection observed in ～90% of all infected humans.
机译：非人类灵长类动物被用来建立一个模仿人类结核分枝杆菌感染的动物模型。食蟹猕猴被低剂量的有毒的 M感染。支气管镜向肺内滴入肺结核。基于结核菌素皮肤测试转换和对 M的外周免疫反应，所有猴子均成功感染。结核抗原。在研究的17只猴子中感染的进展是可变的。在50％至60％的猴子中观察到的慢性慢性感染的特征是，在连续胸部X线照片和其他检查中表现出明显的感染或疾病迹象，并以最终进展为晚期疾病为特征。尽管在最初的研究中显然感染了猴子，但大约有40％的猴子在15到20个月的研究中没有进展为疾病。这些猴子具有人类潜伏性结核的临床特征。食蟹猕猴的低剂量感染似乎代表了人类 M的全谱。结核感染，将成为研究这种感染的发病机理和免疫学的极好模型。另外，该模型将提供研究潜伏的 M的机会。在约90％的感染人类中发现了结核病感染。

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