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首页> 外文期刊>Infection and immunity >Enhanced Immunogenicity to Mycobacterium tuberculosis by Vaccination with an Alphavirus Plasmid Replicon Expressing Antigen 85A
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Enhanced Immunogenicity to Mycobacterium tuberculosis by Vaccination with an Alphavirus Plasmid Replicon Expressing Antigen 85A

机译:通过表达抗原85A的α病毒质粒复制子接种疫苗增强了对结核分枝杆菌的免疫原性

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The immunogenicity of a plasmid DNA vaccine incorporating Sindbis virus RNA replicase functions (pSINCP) and expressing antigen 85A (Ag85A) from Mycobacterium tuberculosis was compared with a conventional plasmid DNA vector encoding Ag85A. pSINCP-85A was highly immunogenic in mice and gave enhanced long-term protection against M. tuberculosis compared with the conventional vector.
机译:将具有Sindbis病毒RNA复制酶功能(pSINCP)并表达结核分枝杆菌的抗原85A(Ag85A)的质粒DNA疫苗的免疫原性与编码Ag85A的常规质粒DNA载体进行了比较。 pSINCP-85A在小鼠中具有高度免疫原性,并增强了针对 M的长期保护。与常规载体相比

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