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首页> 外文期刊>Infection and immunity >Correlation of Susceptibility of Immature Mice to Fungal Infection (Blastomycosis) and Effector Cell Function
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Correlation of Susceptibility of Immature Mice to Fungal Infection (Blastomycosis) and Effector Cell Function

机译：未成熟小鼠对真菌感染（沙门氏菌病）的敏感性与效应细胞功能的相关性

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Immature mice are highly susceptible to blastomycosis, which is similar to other mycoses and has parallels in humans. The murine susceptibility is noteworthy in that it persists beyond the development of resistance to other, nonfungal pathogens and the maturation of most immune functions. As the susceptibility to blastomycosis appeared to be related to an early event after infection, primary effector cell function was studied. We found that peritoneal inflammatory cells, enriched for neutrophils, from immature (3-week-old) mice killed nonphagocytizable Blastomyces dermatitidis cells less (25%) than did cells from mature (8-week) mice (70%) (P < 0.01), a defect intrinsic to the neutrophils. This correlated with an impaired immature cell oxidative burst. Killing of phagocytizable Candida albicans was not significantly different, 73 versus 87%. Thioglycolate-elicited cells were more impaired; killing of B. dermatitidis was insignificant, and killing of C. albicans was more impaired in immature (16% killing) than in mature (45%) cells (P < 0.02). Peripheral blood neutrophils from mature animals killed B. dermatitidis (41%) more than did those from immature animals (10%) (P < 0.02); C. albicans was killed efficiently by both. Resting or activated peritoneal macrophages from both types of animals showed no differences in B. dermatitidis killing. These results suggest that the susceptibility of immature mice is related at least in part to the depressed capacity of their neutrophils to kill B. dermatitidis.
机译：未成熟的小鼠高度敏感于芽孢杆菌病，这与其他霉菌病相似，与人类相似。鼠的易感性值得注意，因为它的持续发展超出了对其他非真菌病原体的抵抗力以及大多数免疫功能的成熟程度。由于对芽孢杆菌病的敏感性似乎与感染后的早期事件有关，因此研究了主要的效应细胞功能。我们发现，来自未成熟（3周龄）小鼠的富含中性粒细胞的腹膜炎性细胞杀死不可吞噬的 Blastomyces dermatitidis 细胞比成熟（8周）小鼠的细胞少（25％）（ 70％）（ P <0.01），这是中性粒细胞固有的缺陷。这与受损的未成熟细胞氧化爆发有关。吞噬可吞噬的白色念珠菌的杀死率无显着差异，分别为73％和87％。巯基乙酸盐诱导的细胞受损更大;杀死 B。皮肤病微不足道，并且杀死了 C。与未成熟（45％）细胞（ P <0.02）相比，未成熟（杀死16％）的白念珠受损程度更大。来自成熟动物的外周血中性粒细胞杀死了 B。皮肤病（41％）比未成熟动物的皮肤病（10％）高（ P <0.02）; C。白化病被双方有效杀死。来自两种类型动物的静止或活化的腹膜巨噬细胞在 B中均无差异。皮肤病杀死。这些结果表明，未成熟小鼠的易感性至少部分与其嗜中性粒细胞杀死 B的能力降低有关。皮肤炎。

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