• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Enhanced Interleukin-12 and CD40 Ligand Activities but Reduced Staphylococcus aureus Cowan 1-Induced Responses Suggest a Generalized and Progressively Impaired Type 1 Cytokine Pattern for Human Schistosomiasis
【24h】

Enhanced Interleukin-12 and CD40 Ligand Activities but Reduced Staphylococcus aureus Cowan 1-Induced Responses Suggest a Generalized and Progressively Impaired Type 1 Cytokine Pattern for Human Schistosomiasis

机译：增强的白细胞介素12和CD40配体活性，但减少金黄色葡萄球菌Cowan 1诱导的反应表明人类血吸虫病的普遍和逐步受损的1型细胞因子模式。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Whole-blood-cell cultures from schistosomiasis patients were stimulated with a variety of T-cell-dependent and T-cell-independent stimuli to determine whether the defect in type 1 cytokine expression observed following helminth infection is associated with alterations in interleukin-12 (IL-12) or CD40 ligand (CD40L) responsiveness. Cultures from uninfected individuals produced abundant gamma interferon in response to Staphylococcus aureus Cowan 1 (SAC), while patients with intestinal and hepatosplenic disease displayed intermediate and weak responses, respectively. Importantly, the decrease in type 1 cytokine expression was not attributed to defects in IL-12- or CD40L-induced activity. Indeed, schistosomiasis patients displayed heightened responses and even produced more biologically active IL-12 when stimulated with SAC and CD40L than did uninfected controls. Finally, additional studies suggested only a partial role for IL-10, since intestinal patients were the only group that overproduced this downregulatory cytokine. Together, these studies demonstrate that the type 1 deficiency in chronic hepatosplenic schistosomiasis is not related to specific defects in IL-12, IL-10, or CD40L activity, although changes in the functional status of antigen-presenting cells appear to be involved.
机译：血吸虫病患者的全血细胞培养物受到各种T细胞依赖性和T细胞非依赖性刺激的刺激，以确定蠕虫感染后观察到的1型细胞因子表达缺陷是否与白介素12的改变有关（ IL-12）或CD40配体（CD40L）响应。来自未感染个体的培养物对金黄色葡萄球菌 Cowan 1（SAC）产生大量的γ干扰素，而肠道和肝脾疾病患者分别表现出中等和弱反应。重要的是，1型细胞因子表达的下降并非归因于IL-12或CD40L诱导的活性的缺陷。确实，血吸虫病患者用SAC和CD40L刺激后，与未感染的对照相比，反应增强，甚至产生更具生物活性的IL-12。最后，其他研究表明，IL-10仅具有部分作用，因为肠道患者是唯一产生这种下调细胞因子的人群。总之，这些研究表明，慢性肝脾性血吸虫病的1型缺陷与IL-12，IL-10或CD40L活性的特定缺陷无关，尽管似乎涉及抗原呈递细胞功能状态的改变。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号