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首页> 外文期刊>Infection and immunity >Visualization of Proteus mirabilis within the Matrix of Urease-Induced Bladder Stones during Experimental Urinary Tract Infection
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Visualization of Proteus mirabilis within the Matrix of Urease-Induced Bladder Stones during Experimental Urinary Tract Infection

机译：实验性尿路感染期间尿素酶诱导的膀胱结石基质中变形杆菌的可视化

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摘要

The virulence of a urease-negative mutant of uropathogenic Proteus mirabilis and its wild-type parent strain was assessed by using a CBA mouse model of catheterized urinary tract infection. Overall, catheterized mice were significantly more susceptible than uncatheterized mice to infection by wild-type P. mirabilis. At a high inoculum, the urease-negative mutant successfully colonized bladders of catheterized mice but did not cause urolithiasis and was still severely attenuated in its ability to ascend to kidneys. Using confocal laser scanning microscopy and scanning electron microscopy, we demonstrated the presence of P. mirabilis within the urease-induced stone matrix. Alizarin red S staining was used to detect calcium-containing deposits in bladder and kidney tissues of P. mirabilis-infected mice.
机译：通过使用尿道导管感染的CBA小鼠模型评估了尿路致病性变形杆菌的尿素酶阴性突变体及其野生型亲本毒力。总体而言，导管插入的小鼠比未导管插入的小鼠更容易受到野生型 P的感染。奇迹。在高接种量下，脲酶阴性突变体成功地定植在导管小鼠的膀胱中，但没有引起尿石症，并且其升至肾脏的能力仍然严重减弱。使用共聚焦激光扫描显微镜和扫描电子显微镜，我们证明了 P的存在。脲酶诱导的石基质中的奇异菌。茜素红S染色用于检测 P膀胱和肾脏组织中的钙沉积。感染了奇异菌的小鼠。

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