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首页> 外文期刊>Infection and immunity >A Salmonella enterica Serovar Typhimurium Translocated Leucine-Rich Repeat Effector Protein Inhibits NF-κB-Dependent Gene Expression
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A Salmonella enterica Serovar Typhimurium Translocated Leucine-Rich Repeat Effector Protein Inhibits NF-κB-Dependent Gene Expression

机译：沙门氏菌血清型鼠伤寒沙门氏菌富含亮氨酸的重复效应蛋白抑制NF-κB依赖性基因表达。

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Nontyphoidal salmonellae are enteric pathogens that cause acute gastroenteritis and colonize the intestinal tract for prolonged periods. In the intestinal epithelia, these bacteria induce secretion of proinflammatory cytokines, such as interleukin-8 (IL-8), which leads to a profound inflammatory response through recruitment of polymorphonuclear leukocytes. Production of IL-8 induced by Salmonella spp. is due to the activation of the transcription factors nuclear factor κB (NF-κB) and activator protein-1 (AP-1). This work demonstrates that Salmonella enterica serovar Typhimurium can downmodulate IL-8 production after invasion of intestinal epithelial cells. The Salmonella translocated effector proteins SspH1 and SptP participate in this process. SspH1 is a member of the bacterial LPX repeat protein family that localizes to the mammalian nucleus and inhibits NF-κB-dependent gene expression. A Shigella flexneri translocated effector, IpaH9.8, which has a similar structure and subcellular localization in mammalian cells, also inhibits NF-κB-dependent gene expression. We propose that suppression of inflammatory responses by intracellular S. enterica serovar Typhimurium, and perhaps Shigella flexneri, contributes to bacterial colonization of host tissues and pathogenesis.
机译：非伤寒沙门氏菌是引起急性胃肠炎并长时间定植于肠道的肠道病原体。在肠道上皮细胞中，这些细菌诱导促炎细胞因子（如白介素8（IL-8））的分泌，通过募集多形核白细胞导致深刻的炎症反应。沙门氏菌引起的IL-8的产生。是由于转录因子核因子κB（NF-κB）和激活蛋白1（AP-1）的激活。这项工作表明肠沙门氏菌血清型鼠伤寒沙门氏菌可以在肠上皮细胞侵袭后下调IL-8的产生。 沙门氏菌易位效应蛋白SspH1和SptP参与此过程。 SspH1是细菌LPX重复蛋白家族的成员，该家族位于哺乳动物细胞核内并抑制NF-κB依赖性基因的表达。 弗氏志贺氏菌易位效应子IpaH9.8在哺乳动物细胞中具有相似的结构和亚细胞定位，也抑制NF-κB依赖性基因表达。我们建议通过细胞内 S抑制炎症反应。肠杆菌血清型鼠伤寒，也许是弗氏志贺氏菌，有助于宿主组织的细菌定植和发病机理。

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