Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture.

A Sugiyama; R Arakaki; T Ohnishi; N Arakaki; Y Daikuhara; H Takada

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Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture.

机译：脂磷壁酸和白介素1协同刺激培养的人牙龈成纤维细胞中肝细胞生长因子（散射因子）的产生。

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Lipoteichoic acids (LTA) from various gram-positive bacteria, including oral streptococci such as Streptococcus sanguis, enhanced the production of hepatocyte growth factor (HGF) (scatter factor) by human gingival fibroblasts in culture, whereas lipopolysaccharides (LPS) from various gram-negative bacteria did not. In contrast, LPS induced interleukin 1 activity in human gingival epithelial cells in culture, while LTA had little effect. LTA and recombinant human interleukin 1 alpha enhanced synergistically the production of HGF/SF in human gingival fibroblast cultures. Recombinant human HGF, in turn, enhanced the proliferation of human gingival epithelial cells in culture.

机译：来自各种革兰氏阳性细菌的脂蛋白酸（LTA），包括口服链球菌，如血链球菌，可提高培养的人牙龈成纤维细胞产生肝细胞生长因子（HGF）（散射因子）的能力，而来自各种革兰氏阳性菌的脂多糖（LPS）阴性细菌没有。相反，LPS诱导培养的人牙龈上皮细胞中的白介素1活性，而LTA作用不大。 LTA和重组人白介素1α在人牙龈成纤维细胞培养物中协同增强HGF / SF的产生。重组人HGF反过来增强了培养物中人牙龈上皮细胞的增殖。

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《Infection and immunity》 |1996年第4期|共6页
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A Sugiyama; R Arakaki; T Ohnishi; N Arakaki; Y Daikuhara; H Takada;
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1. Arginine-Specific Gingipains from Porphyromonas gingivalis Stimulate Production of Hepatocyte Growth Factor (Scatter Factor) through Protease-Activated Receptors in Human Gingival Fibroblasts in Culture. [J] . Uehara A, Muramoto K, Imamura T, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2005,第9期

机译：来自牙龈卟啉单胞菌的精氨酸特异性姜黄素通过培养的人牙龈成纤维细胞中的蛋白酶激活受体刺激肝细胞生长因子（散射因子）的产生。
2. Arginine-Specific Gingipains from Porphyromonas gingivalis Stimulate Production of Hepatocyte Growth Factor (Scatter Factor) through Protease-Activated Receptors in Human Gingival Fibroblasts in Culture [J] . Akiko Uehara, Koji Muramoto, Takahisa Imamura, The journal of immunology . 2005,第9期

机译：牙龈卟啉单胞菌的精氨酸特异姜黄素通过蛋白酶激活人牙龈成纤维细胞中的受体刺激肝细胞生长因子（散射因子）的产生。
3. Signal transduction pathways involved in the synergistic stimulation of prostaglandin production by interleukin-1beta and tumor necrosis factor alpha in human gingival fibroblasts. [J] . Yucel Lindberg-T, Nilsson S, Modeer T Journal of Dental Research: Official Publication of the International Association for Dental Research . 1999,第1期

机译：信号转导通路参与人牙龈成纤维细胞中白介素-1β和肿瘤坏死因子α协同刺激前列腺素产生。
4. Synergistic effects of prostaglandin Ei (PGEx) orPGE2 and dexamethasone on keratinocyte growthfactor (KGF) production by gingival fibroblasts [C] . Mitsuhiro Ohshima, Yoko Yamaguchi, Kichibee Otsuk International Symposium for Interface Oral Health Science . 2005

机译：前列腺素ei（PGEX）ORPGE2和地塞米松对角质形成细胞生长活性仪（KGF）产生的协同作用牙龈成纤维细胞
5. Synergistic stimulation of mitogenesis of human airway smooth muscle cells by lysophosphatidic acid and epidermal growth factor. [D] . Ediger, Tracy L. 2001

机译：溶血磷脂酸和表皮生长因子协同刺激人气道平滑肌细胞的有丝分裂。
6. Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture. [O] . A Sugiyama, R Arakaki, T Ohnishi, 1996

机译：脂磷壁酸和白介素1协同刺激培养的人牙龈成纤维细胞中肝细胞生长因子（散射因子）的产生。
7. Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture [O] . A Sugiyama, R Arakaki, T Ohnishi, 1996

机译：脂素酸和白细胞介素1刺激培养中人牙龈成纤维细胞中肝细胞生长因子（散射因子）的协同产生
8. Autocrine Stimulation of Interleukin-1(alpha) and Transforming Growth Factor(alpha) Production in Human Keratinocytes and Its Antagonism by Glucocorticoids. [R] . Lee, S. W., Morhenn, V. B., Ilnicka, M., 1989

机译：自分泌刺激人角质形成细胞中白细胞介素-1（α）和转化生长因子（α）的产生及其对糖皮质激素的拮抗作用。

Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture.

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