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首页> 外文期刊>Infection and immunity >Protection by CD4 or CD8 T Cells against PulmonaryMycobacterium bovis Bacillus Calmette-Guérin Infection
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Protection by CD4 or CD8 T Cells against PulmonaryMycobacterium bovis Bacillus Calmette-Guérin Infection

机译：CD4或CD8 T细胞对牛分枝杆菌卡介苗的感染的保护

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摘要

Mice deficient in CD8 T cells demonstrated levels of Th1 cytokines and granulomatous responses in the lungs very similar to those demonstrated by normal control mice and were fully capable of controlling pulmonary mycobacterial infection by Mycobacterium bovis BCG as assessed at day 37 postinfection. In comparison, mice deficient in CD4 T cells had similar levels of interleukin-12 (IL-12) and tumor necrosis factor alpha but lower levels of gamma interferon in the lungs and were still able to mount tissue granulomatous responses and control pulmonary mycobacterial infection. In contrast, IL-12?/? mice with impaired CD4 and CD8 T-cell responses had a markedly weakened control of infection, whereas SCID mice deficient in all T cells succumbed to such pulmonary mycobacterial infections.
机译：缺乏CD8 T细胞的小鼠在肺中显示Th1细胞因子水平和肉芽肿反应，与正常对照小鼠所显示的相似，并且完全能够控制牛分枝杆菌 BCG的肺分枝杆菌感染37感染后。相比之下，缺乏CD4 T细胞的小鼠的白细胞介素12（IL-12）和肿瘤坏死因子α的水平相似，但肺中的γ干扰素水平较低，并且仍然能够引起组织肉芽肿性反应并控制肺分支杆菌感染。相比之下，CD4和CD8 T细胞反应受损的IL-12 α/β小鼠的感染控制能力明显减弱，而所有T细胞缺陷的SCID小鼠都死于这种肺分枝杆菌感染。

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