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首页> 外文期刊>Infection and immunity >Comparison of Escherichia coli Strains Recovered from Human Cystitis and Pyelonephritis Infections in Transurethrally Challenged Mice
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Comparison of Escherichia coli Strains Recovered from Human Cystitis and Pyelonephritis Infections in Transurethrally Challenged Mice

机译：从人膀胱炎和肾盂肾炎感染中经尿道感染的小鼠中回收的大肠杆菌菌株的比较

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Urinary tract infection, most frequently caused byEscherichia coli, is one of the most common bacterial infections in humans. A vast amount of literature regarding the mechanisms through which E. coli induces pyelonephritis has accumulated. Although cystitis accounts for 95% of visits to physicians for symptoms of urinary tract infections, few in vivo studies have investigated possible differences between E. coli recovered from patients with clinical symptoms of cystitis and that from patients with symptoms of pyelonephritis. Epidemiological studies indicate that cystitis-associated strains appear to differ from pyelonephritis-associated strains in elaboration of some putative virulence factors. With transurethrally challenged mice we studied possible differences using three each of the most virulent pyelonephritis and cystitis E. coli strains in our collection. The results indicate that cystitis strains colonize the bladder more rapidly than do pyelonephritis strains, while the rates of kidney colonization are similar. Cystitis strains colonize the bladder in higher numbers, induce more pronounced histologic changes in the bladder, and are more rapidly eliminated from the mouse urinary tract than pyelonephritis strains. These results provide evidence that cystitis strains differ from pyelonephritis strains in this model, that this model is useful for the study of the uropathogenicity of cystitis strains, and that it would be unwise to use pyelonephritis strains to study putative virulence factors important in the development of cystitis.
机译：泌尿道感染，最常见由大肠杆菌引起，是人类最常见的细菌感染之一。关于 E的机制的大量文献。大肠杆菌诱发肾盂肾炎的累积。尽管膀胱炎占泌尿道感染症状就医人数的95％，但很少有体内研究调查过 E之间可能的差异。从患有膀胱炎临床症状和肾盂肾炎症状的患者中回收大肠杆菌。流行病学研究表明，与膀胱炎相关的菌株似乎与肾盂肾炎相关的菌株在某些假定毒力因子的阐述上有所不同。对于经尿道感染的小鼠，我们研究了三种毒性最强的肾盂肾炎和膀胱炎 E的可能差异。我们收集的大肠杆菌菌株。结果表明，膀胱炎菌株比肾盂肾炎菌株更快地在膀胱中定植，而肾脏定植的速率相似。与肾盂肾炎菌株相比，膀胱炎菌株以更高的数量在膀胱中定植，在膀胱中引起更明显的组织学变化，并且从小鼠泌尿道被更快地消除。这些结果提供了证据，证明该模型中的膀胱炎菌株不同于肾盂肾炎菌株，该模型可用于研究膀胱炎菌株的尿路致病性，并且不建议使用肾盂肾炎菌株来研究推定对人类肾炎的重要毒力因子。膀胱炎。

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