Latency-Associated Peptide of Transforming Growth Factor β Enhances Mycobacteriocidal Immunity in the Lung duringMycobacterium bovis BCG Infection in C57BL/6 Mice

K. A. Wilkinson; T. D. Martin; S. M. Reba; H. Aung; R. W. Redline; W. H. Boom; Z. Toossi; S. A. Fulton

首页> 外文期刊>Infection and immunity >Latency-Associated Peptide of Transforming Growth Factor β Enhances Mycobacteriocidal Immunity in the Lung duringMycobacterium bovis BCG Infection in C57BL/6 Mice

【24h】

Latency-Associated Peptide of Transforming Growth Factor β Enhances Mycobacteriocidal Immunity in the Lung duringMycobacterium bovis BCG Infection in C57BL/6 Mice

机译：转化生长因子β的潜伏相关肽增强了C57BL / 6小鼠牛分枝杆菌BCG感染过程中肺的分枝杆菌免疫。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Latency-associated peptide of transforming growth factor β (TGF-β) (LAP) was used to determine whether in vivo modulation of TGF-β bioactivity enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptibility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-β.

机译：使用转化生长因子β（TGF-β）（LAP）的潜伏期相关肽来确定体内TGF-β生物活性的调节是否增强了C57BL / 6小鼠对牛分枝杆菌BCG感染的肺部免疫力。 LAP降低了肺中BCG的生长，并增强了抗原特异性T细胞增殖和伽马干扰素mRNA表达。因此，TGF-β的免疫抑制作用可能部分介导了肺部对原发性BCG感染的敏感性。

著录项

来源
《Infection and immunity》 |2000年第11期|共4页
作者
K. A. Wilkinson; T. D. Martin; S. M. Reba; H. Aung; R. W. Redline; W. H. Boom; Z. Toossi; S. A. Fulton;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. The recombinant proregion of transforming growth factor β1 (Latency-associated peptide) inhibits active transforming growth factor β1 in transgenic mice [J] . Erwin P. Bottinger, Valentina M. Factor, Monica L.-S. Tsang Proceedings of the National Academy of Sciences of the United States of America . 1996,第12期

机译：转化生长因子β1（潜伏期相关肽）的重组前区抑制转基因小鼠中的活性转化生长因子β1
2. Genetically Determined Disparate Innate and Adaptive Cell-Mediated Immune Responses to Pulmonary Mycobacterium bovis BCG Infection in C57BL/6 and BALB/c Mice [J] . Julia Wakeham, Jun Wang, Zhou Xing Infection and immunity . 2000,第12期

机译：遗传确定的不同的先天性和适应性细胞介导的C57BL / 6和BALB / c小鼠对牛分枝杆菌BCG感染的免疫反应
3. Genetically Determined Disparate Innate and Adaptive Cell-Mediated Immune Responses to Pulmonary Mycobacterium bovis BCG Infection in C57BL/6 and BALB/c Mice [J] . Julia Wakeham, Jun Wang, Zhou Xing Infection and immunity . 2000,第12期

机译：遗传确定的不同的先天性和适应性细胞介导的C57BL / 6和BALB / c小鼠对牛分枝杆菌BCG感染的免疫反应
4. Metabolomics approach for mice serum associated with epidermal growth factor receptor and BaP-induced mouse lung tumorigenesis using liquid chromatography-mass spectrometry [C] . Pinpin Lin, Chao-Yu Chen, Jhih-Sheng Chen, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用液相色谱 - 质谱法与表皮生长因子受体相关的小鼠血清的代谢组种方法，液相色谱 - 质谱法
5. Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice [D] . Boonyarattanasoonthorn, Tussapon 2019

机译：C57BL / 6和DBA / 2小鼠对肺炎支原体感染的细胞免疫应答分析
6. Note: Latency-Associated Peptide of Transforming Growth Factor β Enhances Mycobacteriocidal Immunity in the Lung during Mycobacterium bovis BCG Infection in C57BL/6 Mice [O] . K. A. Wilkinson, T. D. Martin, S. M. Reba, 2000

机译：注意：转化生长因子β的潜伏期相关肽增强了C57BL / 6小鼠牛分枝杆菌BCG感染过程中肺的分枝杆菌免疫力。
7. Latency-Associated Peptide of Transforming Growth Factor β Enhances Mycobacteriocidal Immunity in the Lung during Mycobacterium bovis BCG Infection in C57BL/6 Mice [O] . K. A. Wilkinson, T. D. Martin, S. M. Reba, 2000

机译：转化生长因子β的潜伏期相关肽增强了C57BL / 6小鼠中肉杆菌BCG感染期间肺部的分枝杆菌免疫
8. Effect of Local Ultraviolet Irradiation on Infections of Mice with 'Candida albicans', 'Mycobacterium bovis BCG', and 'Schistosoma mansoni' [R] . Jeevan, A., Evans, R., Brown, E. L., 1992

机译：局部紫外线照射对'白色念珠菌'，'牛分枝杆菌BCG'和'曼氏血吸虫'小鼠感染的影响

Latency-Associated Peptide of Transforming Growth Factor β Enhances Mycobacteriocidal Immunity in the Lung duringMycobacterium bovis BCG Infection in C57BL/6 Mice

摘要

著录项

相似文献

相关主题

期刊订阅