Evidence consistent with horizontal transfer of the gene (emm12) encoding serotype M12 protein between group A and group G pathogenic streptococci.

W J Simpson; J M Musser; P P Cleary

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Evidence consistent with horizontal transfer of the gene (emm12) encoding serotype M12 protein between group A and group G pathogenic streptococci.

机译：证据与A组和G组致病性链球菌之间编码M12血清型的基因（emm12）的水平转移一致。

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Human isolates of Lancefield group G streptococci harbor sequences homologous with the structural gene (emm) encoding M protein, a major virulence factor in Streptococcus pyogenes (a group A Streptococcus species). We used DNA-DNA hybridization, restriction endonuclease chromosomal profiling, and multilocus enzyme electrophoresis to examine genetic relationships between group A and group G streptococcal strains expressing homologous serologic type 12 M (M12) protein. All M12 group A strains studied had very similar restriction endonuclease genomic profiles and multilocus enzyme genotypes. In contrast, the restriction enzyme genomic profile and multilocus enzyme genotype of the M12 group G strain CS140 were strikingly different from those characterizing the M12 group A organisms. DNA-DNA hybridization studies revealed, on average, 57% genomic similarity between the M12 group A and group G strains. Taken together, our data demonstrate that a gene encoding M12 protein occurs in two highly divergent chromosomal backgrounds, a result suggesting that an episode of horizontal gene transfer and recombination has occurred between two streptococcal lineages.

机译：Lancefield组G链球菌港口序列的人类分离株与编码M蛋白（化脓性链球菌（A组链球菌属）的主要毒力因子）的结构基因（emm）同源。我们使用DNA-DNA杂交，限制性核酸内切酶染色体分析和多位酶电泳来检查A组和G组表达同源血清型12 M（M12）蛋白的链球菌菌株之间的遗传关系。研究的所有M12 A组菌株均具有非常相似的限制性核酸内切酶基因组图谱和多基因座酶基因型。相反，M12组G菌株CS140的限制性酶基因组谱和多基因座酶基因型与表征M12组A的那些显着不同。 DNA-DNA杂交研究显示，M12 A组和G组菌株之间平均有57％的基因组相似性。两者合计，我们的数据表明，编码M12蛋白的基因出现在两个高度不同的染色体背景中，结果表明在两个链球菌谱系之间发生了水平基因转移和重组。

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《Infection and immunity》 |1992年第5期|共4页
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W J Simpson; J M Musser; P P Cleary;
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1. Characterization of a Complement-Binding Protein, DRS, from Strains of Streptococcus pyogenes Containing the emm12 and emm55 Genes [J] . Michael Binks, K. S. Sriprakash Infection and immunity . 2004,第7期

机译：含有emm12和emm55基因的化脓性链球菌菌株的补体结合蛋白DRS的表征
2. Streptococcus pyogenes strains containing emm12 and emm55 possess a novelgene coding for distantly related SIC protein [J] . Hartas J., Sriprakash KS. Microbial Pathogenesis . 1999,第1期

机译：含有emm12和emm55的化脓链球菌菌株具有编码远距离相关SIC蛋白的新基因
3. Horizontal transfer of virulence genes encoded on the Enterococcus faecalis pathogenicity island [J] . Coburn PS, Baghdayan AS, Dolan GT, Molecular Microbiology . 2007,第2期

机译：粪肠球菌致病岛上编码的毒力基因的水平转移
4. Functional characterization of DRS from Streptococcus pyogenes M12 and M55 serotypes [C] . Michael J. Binks, Barbara A. Fernie-King, David J. Seilly, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：来自链球菌Pyogenes M12和M55血清型的DRS的功能表征
5. Horizontal transfer of extended-spectrum beta-lactamase- and carbapenemase-encoding gene in Klebsiella pneumoniae in raw foods. [D] . Jung, Yang Jin. 2016

机译：生食品中肺炎克雷伯菌中广谱β-内酰胺酶和碳青霉烯酶编码基因的水平转移。
6. Evidence consistent with horizontal transfer of the gene (emm12) encoding serotype M12 protein between group A and group G pathogenic streptococci. [O] . W J Simpson, J M Musser, P P Cleary 1992

机译：证据与A组和G组致病性链球菌之间编码M12血清型蛋白的基因（emm12）水平转移一致。
7. Characterization of a Complement-Binding Protein, DRS, from Strains of Streptococcus pyogenes Containing the emm12 and emm55 Genes [O] . Binks, Michael, Sriprakash, K. S. 2004

机译：含有emm12和emm55基因的化脓链球菌菌株的补体结合蛋白DRS的表征

Evidence consistent with horizontal transfer of the gene (emm12) encoding serotype M12 protein between group A and group G pathogenic streptococci.

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