Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria.

D E Lanar; J A Tine; C de Taisne; M C Seguin; W I Cox; J P Winslow; L A Ware; E B Kauffman; D Gordon; W R Ballou; E Paoletti; J C Sadoff

首页> 外文期刊>Infection and immunity >Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria.

【24h】

Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria.

机译：减毒的痘苗病毒-子孢子蛋白重组体可预防啮齿动物的疟疾。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

NYVAC-based vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Plasmodium berghei rodent malaria model system. Immunization of mice with a NYVAC-based CSP recombinant elicited a high level of protection (60 to 100%). Protection did not correlate with CS repeat-specific antibody responses and was abrogated by in vivo CD8+ T-cell depletion. Protection was not enhanced by modification of the subcellular localization of CSP. These results suggest the potential of poxvirus-based vectors for the development of vaccine candidates for human malaria.

机译：表达了环子孢子蛋白（CSP）的基于NYVAC的痘苗病毒重组体在伯氏疟原虫啮齿动物疟疾模型系统中进行了评估。使用基于NYVAC的CSP重组体对小鼠进行免疫可产生高水平的保护（60％至100％）。保护与CS重复特异性抗体反应无关，并通过体内CD8 + T细胞耗竭而被废除。通过修饰CSP的亚细胞定位不能增强保护作用。这些结果表明基于痘病毒的载体在开发人类疟疾候选疫苗方面的潜力。

著录项

来源
《Infection and immunity》 |1996年第5期|共6页
作者
D E Lanar; J A Tine; C de Taisne; M C Seguin; W I Cox; J P Winslow; L A Ware; E B Kauffman; D Gordon; W R Ballou; E Paoletti; J C Sadoff;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Recombinant A27 protein synergizes with modified vaccinia Ankara in conferring protection against a lethal vaccinia virus challenge. [J] . He Y., Meseda C. A., Vassell R. A., Vaccine . 2010,第3期

机译：重组A27蛋白与修饰的牛痘Ankara协同作用，赋予针对致命牛痘病毒的保护作用。
2. A nonadjuvanted polypeptide nanoparticle vaccine confers long-lasting protection against rodent malaria. [J] . Kaba SA, Brando C, Guo Q, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2009,第11期

机译：非佐剂多肽纳米颗粒疫苗可提供针对啮齿动物疟疾的长期保护。
3. A nonadjuvanted polypeptide nanoparticle vaccine confers long-lasting protection against rodent malaria. [J] . Kaba SA, Brando C, Guo Q, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2009,第11期

机译：非佐剂多肽纳米颗粒疫苗可提供针对啮齿动物疟疾的长期保护。
4. Humanized Recombinant Vaccinia Virus Complement Control Protein (hrVCP) with Three Amino Acid Changes, H98Y, E102K, and E120K Creating an Additional Putative Heparin Binding Site, Is 100-fold More Active Than rVCP in Blocking Both Classical and Alternative Complement Pathways [C] . YOHANNES T. GHEBREMARIAM, ODUTAYO O. ODUNUGA, KRISTEN JANSE, International Conference on Natural Products and Molecular Medicine . 2005

机译：人源化重组疫苗病毒补蛋白（HRVCP）具有三个氨基酸变化，H98Y，E102K和E120K产生另外的肝素结合位点，比RVCP在阻断经典和替代的补体途径时，100倍。
5. Cloning and evaluation of Vibrio cholerae surface proteins in conferring protection against experimental cholera. [D] . Das, Margaret. 1998

机译：霍乱弧菌表面蛋白的克隆和评估，以赋予对实验霍乱的保护作用。
6. Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria. [O] . D E Lanar, J A Tine, C de Taisne, 1996

机译：减毒的痘苗病毒-子孢子蛋白重组体可预防啮齿动物的疟疾。
7. Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria [O] . D E Lanar, J A Tine, C de Taisne, 1996

机译：减毒的痘苗病毒 - 普通孢子蛋白质重组剂赋予啮齿动物疟疾的保护

Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria.

摘要

著录项

相似文献

相关主题

期刊订阅