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Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro.

机译:活细胞和死细胞内细菌体外诱导巨噬细胞衍生的细胞因子的差异。

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Marked differences in the abilities of living and heat-killed Brucella abortus and Listeria monocytogenes organisms to induce production of tumor necrosis factor alpha by in vitro-cultured macrophages were observed. Interleukin-1 and interleukin-6 appeared to be under different control. The results are discussed in relation to the induction of gamma interferon-producing Th1 cells and acquired cellular resistance to infection by living vaccines but not killed vaccines.
机译:观察到活的和热灭活的布鲁氏菌和单核细胞增生李斯特菌生物体在体外培养巨噬细胞诱导产生肿瘤坏死因子α的能力上存在明显差异。白介素-1和白介素-6似乎处于不同的控制之下。讨论了有关产生γ干扰素的Th1细胞的诱导以及获得的细胞对活疫苗而非杀伤疫苗感染的抗性的结果。

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