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首页> 外文期刊>Infection and immunity >The predicted amino acid sequence of the Salmonella typhimurium virulence gene mviAA(+) strongly indicates that MviA is a regulator protein of a previously unknown S. typhimurium response regulator family.
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The predicted amino acid sequence of the Salmonella typhimurium virulence gene mviAA(+) strongly indicates that MviA is a regulator protein of a previously unknown S. typhimurium response regulator family.

机译：鼠伤寒沙门氏菌毒力基因mviAA（+）的预测的氨基酸序列强烈表明，MviA是以前未知的鼠伤寒沙门氏菌应答调节基因家族的调节蛋白。

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摘要

The Salmonella typhimurium virulence gene mviA+ has a predicted amino acid sequence with homology to the N-terminal 112-amino-acid sequence of response regulator proteins. A previously described mutant allele (mviA), which restores virulence to avirulent LT2 strains, was shown to contain a point mutation which would be predicted to cause a single amino acid change, V-102-->G (W. H. Benjamin, Jr., J. Yother, P. Hall, and D. E. Briles, J. Exp. Med. 1,74:1073-1083, 1991). A comparison of the nucleotide sequence of mviA+ with that of the Escherichia coli and Salmonella typhi genes revealed a high degree of conservation.
机译：鼠伤寒沙门氏菌毒力基因mviA +具有预测的氨基酸序列，该序列与应答调节蛋白的N端112个氨基酸序列具有同源性。先前描述的突变等位基因（mviA）可将毒力恢复为无毒LT2菌株，已显示其包含点突变，该突变有望导致单个氨基酸变化，即V-102-> G（WH Benjamin，Jr.， J.Yother，P.Hall和DE Briles，J.Exp.Med.1，74：1073-1083，1991）。 mviA +的核苷酸序列与大肠杆菌和伤寒沙门氏菌基因的核苷酸序列比较显示出高度的保守性。

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