In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis.

E Isogai; H Isogal; K Kimura; N Fujii; S Takagi; K Hirose; M Hayashi

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In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis.

机译：通过施用牙龈卟啉单胞菌的脂多糖在体内诱导小鼠凋亡和免疫应答。

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In vivo administration of Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) to mice induced apoptosis before a specific immune response. Apoptosis was associated with the expression of immunoglobulin and Ia on B cells and of CD5 and several markers on T cells. Apoptosis peaked in the spleen and lymph nodes on day 2, and the second peak occurred in the thymus on day 9. Tumor necrosis factor alpha (TNF-alpha) could mediate apoptosis, because the serum TNF-alpha levels were significantly higher than those of controls at 1 day before apoptosis and recombinant murine TNF-alpha induced apoptosis. The apoptosis induced by Pg-LPS was similar to that induced by Escherichia coli LPS in its basic manner, but it was unique in the response of thymus T cells. It was suggested that Pg-LPS could induce apoptosis for the elimination of early nonspecific activated lymphocytes.

机译：在小鼠体内体内施用牙龈卟啉单胞菌脂多糖（Pg-LPS）可以诱导细胞凋亡，然后进行特定的免疫反应。凋亡与B细胞和CD5上的免疫球蛋白和Ia的表达以及T细胞上的几种标志物有关。凋亡在第2天在脾和淋巴结中达到高峰，第二个高峰在第9天在胸腺中发生。肿瘤坏死因子α（TNF-alpha）可以介导细胞凋亡，因为血清TNF-alpha的水平明显高于TNF-α。在凋亡前1天控制小鼠，重组鼠TNF-α诱导凋亡。 Pg-LPS诱导的细胞凋亡在基本方面类似于大肠杆菌LPS诱导的凋亡，但在胸腺T细胞的应答中是独特的。提示Pg-LPS可以诱导凋亡，以消除早期的非特异性活化淋巴细胞。

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《Infection and immunity》 |1996年第4期|共6页
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E Isogai; H Isogal; K Kimura; N Fujii; S Takagi; K Hirose; M Hayashi;
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中图分类医学免疫学;
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1. The role of CD4+ cells in vivo on the induction of the immune response to Porphyromonas gingivalis in mice. [J] . Sosroseno W, Bird PS, Gemmell E, Journal of Periodontology . 2002,第10期

机译：体内CD4 +细胞在诱导小鼠对牙龈卟啉单胞菌的免疫反应中的作用。
2. In vivo induction of apoptosis (programmed cell death) in mouse thymus by administration of lipopolysaccharide. [J] . Y H Zhang, K Takahashi, G Z Jiang, Infection and immunity . 1993,第12期

机译：通过给予脂多糖在体内诱导小鼠胸腺的凋亡（程序性细胞死亡）。
3. In vivo induction of apoptosis (programmed cell death) in mouse thymus by administration of lipopolysaccharide. [J] . Y H Zhang, K Takahashi, G Z Jiang, Infection and immunity . 1993,第12期

机译：通过给予脂多糖在体内诱导小鼠胸腺的凋亡（程序性细胞死亡）。
4. Antidepressants prevent hierarchy destabilization induced by lipopolysaccharide administration in mice: a neurobiological approach to depression [C] . Daniel Wagner Hamada Cohn, Denise Kinoshita, Jo?o Palermo-Neto International Society for Neuroimmunomodulation . 2012

机译：抗抑郁药防止小鼠脂多糖给药诱导的层次破坏稳定：抑郁症的神经生物学方法
5. Matrix metalloproteinase activation and induction in keratinocytes by a purified thiol-proteinase from Porphyromonas gingivalis. [D] . DeCarlo, Arthur Anthony, Jr. 1994

机译：牙龈卟啉单胞菌中纯化的巯基蛋白酶在角质形成细胞中激活基质金属蛋白酶。
6. In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis. [O] . E Isogai, H Isogal, K Kimura, 1996

机译：通过施用牙龈卟啉单胞菌的脂多糖在体内诱导小鼠凋亡和免疫应答。
7. In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis [O] . E Isogai, H Isogal, K Kimura, 1996

机译：通过卟啉糖血管糖尿病施用脂多糖的小鼠凋亡和免疫应答的体内诱导
8. In Vitro Responses of CBA/N Mice: Spleen Cells of Mice with an X-Linked Defect that Precludes Immune Responses to Several Thymus-Independent Antigens can Respond to TNP-Lipopolysaccharide. [R] . Mosier, D. E., Scher, I., Paul, W. E. 1976

机译：CBa / N小鼠的体外反应：具有X连锁缺陷的小鼠脾细胞排除对几种不依赖胸腺的抗原的免疫应答，可响应TNp-脂多糖。

In vivo induction of apoptosis and immune responses in mice by administration of lipopolysaccharide from Porphyromonas gingivalis.

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