Oral immunization with a recombinant cysteine-rich section of the Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence inhibition activity.

D E Beving; C J Soong; J I Ravdin

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Oral immunization with a recombinant cysteine-rich section of the Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence inhibition activity.

机译：用溶组织Entamoeba组织半乳糖可抑制的凝集素的富含半胱氨酸的重组部分进行口服免疫可引起肠道分泌型免疫球蛋白A应答，该应答具有体外粘附抑制活性。

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The LC3-encoded 52-kDa recombinant protein includes amino acids 758 to 1134 of the 170-kDa subunit of the galactose-inhibitable lectin. Oral immunization of BALB/c mice with the LC3-encoded protein and cholera holotoxin induced an intestinal secretory immunoglobulin A (IgA) response (P < 0.01 compared with the control). There was a negative correlation (P = 0.001) between intestinal anti-LC3 IgA and serum IgA and IgG antibody responses. Intestinal secretions from immunized mice completely inhibited the galactose-specific adherence of axenic trophozoites ot Chinese hamster ovary cells (P < 0.01).

机译：LC3编码的52kDa重组蛋白包括可抑制半乳糖的凝集素的170kDa亚基的758-1134位氨基酸。用LC3编码的蛋白和霍乱全毒素对BALB / c小鼠进行口服免疫可引起肠道分泌性免疫球蛋白A（IgA）反应（与对照组相比，P <0.01）。肠道抗LC3 IgA与血清IgA和IgG抗体反应之间呈负相关（P = 0.001）。免疫小鼠的肠道分泌物完全抑制了中国仓鼠卵巢细胞的半乳糖营养子的半乳糖特异性粘附（P <0.01）。

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《Infection and immunity》 |1996年第4期|共4页
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D E Beving; C J Soong; J I Ravdin;
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1. Immunization of rats with the 260-kilodalton Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence-inhibitory activity. [J] . B L Kelsall, J I Ravdin Infection and immunity . 1995,第2期

机译：用260千达尔顿的溶组织性变形杆菌Entamoeba抑制半乳糖的凝集素对大鼠进行免疫，可引起肠道分泌性免疫球蛋白A应答，该应答具有体外粘附抑制活性。
2. Humoral and mucosal IgA antibody response to a recombinant 52-kDa cysteine-rich portion of the Entamoeba histolytica galactose-inhibitable lectin correlates with detection of native 170-kDa lectin antigen in serum of patients with amebic colitis. [J] . Abou el Magd I, Soong CJ, el Hawey AM, The Journal of Infectious Diseases . 1996,第1期

机译：体液和粘膜IgA抗体对重组溶组织性变形杆菌半乳糖抑制型凝集素的富含52kDa半胱氨酸的部分的反应与检测阿米巴性结肠炎患者血清中的天然170-kDa凝集素抗原有关。
3. A recombinant cysteine-rich section of the Entamoeba histolytica galactose-inhibitable lectin is efficacious as a subunit vaccine in the gerbil model of amebic liver abscess. [J] . Soong CJ, Kain KC, Abd Alla M, The Journal of Infectious Diseases . 1995,第3期

机译：在阿米巴性肝脓肿的沙鼠模型中，重组解组织Entamoeba histolytica抑制半乳糖凝集素的富含半胱氨酸的重组部分可有效用作亚单位疫苗。
4. Oral immunization with a recombinant cysteine-rich section of the Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence inhibition activity. [O] . D E Beving, C J Soong, J I Ravdin 1996

机译：口服重组组织虫变形半乳糖抑制半乳糖凝集素的富含半胱氨酸的部分的口服免疫可引起肠道分泌性免疫球蛋白A应答该应答具有体外粘附抑制活性。
5. Oral immunization with a recombinant cysteine-rich section of the Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence inhibition activity [O] . D E Beving, C J Soong, J I Ravdin 1996

机译：用重组半胱氨酸的富含物体溶液的植物溶解型凝胶蛋白的口服免疫引发肠道分泌免疫球蛋白的反应，其具有体外粘附抑制活性的反应

Oral immunization with a recombinant cysteine-rich section of the Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence inhibition activity.

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