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首页> 外文期刊>Infection and immunity >Chronic Active Hepatitis Induced by Helicobacter hepaticus in the A/JCr Mouse Is Associated with a Th1 Cell-Mediated Immune Response
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Chronic Active Hepatitis Induced by Helicobacter hepaticus in the A/JCr Mouse Is Associated with a Th1 Cell-Mediated Immune Response

机译：在A / JCr小鼠中由肝杆菌引起的慢性活动性肝炎与Th1细胞介导的免疫反应有关。

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Helicobacter hepaticus infection in A/JCr mice results in chronic active hepatitis characterized by perivascular, periportal, and parenchymal infiltrates of mononuclear and polymorphonuclear cells. This study examined the development of hepatitis and the immune response of A/JCr mice to H. hepaticus infection. The humoral and cell-mediated T helper immune response was profiled by measuring the postinfection (p.i.) antibody response in serum, feces, and bile and by the production of cytokines and proliferative responses by splenic mononuclear cells to H. hepaticusantigens. Secretory immunoglobulin A (IgA) and systemic IgG2a antibody developed by 4 weeks p.i. and persisted through 12 months. Splenocytes from infected mice proliferated and produced more gamma interferon (IFN-γ) than interleukin-4 (IL-4) or IL-5 when cultured with H. hepaticus outer membrane proteins. The predominantly IgG2a antibody response in serum and the in vitro production of IFN-γ in excess of IL-4 or IL-5 are consistent with a Th1 immune response reported in humans and mice infected withHelicobacter pylori and Helicobacter felis, respectively. Mice infected with H. hepaticus developed progressively severe perivascular, periportal, and hepatic parenchymal lesions consisting of lymphohistiocytic and plasmacytic cellular infiltrates. In addition, transmural typhlitis was observed at 12 months p.i. The characterization of a cell-mediated Th1 immune response toH. hepaticus infection in the A/JCr mouse should prove valuable as a model for experimental regimens which manipulate the host response to Helicobacter.
机译：A / JCr小鼠中的 Helicobacter hepaticus 感染会导致慢性活动性肝炎，其特征是单核细胞和多形核细胞的血管周围，门静脉和实质浸润。这项研究检查了肝炎的发展以及A / JCr小鼠对 H的免疫反应。肝感染。通过测量血清，粪便和胆汁中的感染后（p.i.）抗体反应，以及脾单核细胞对 H的细胞因子产生和增殖反应，来分析体液和细胞介导的T辅助免疫反应。肝抗原。分泌免疫球蛋白A（IgA）和全身性IgG2a抗体在p.i到第4周时出现。并持续了12个月。当与 H培养时，受感染小鼠的脾细胞增殖并产生比白介素4（IL-4）或IL-5更多的γ干扰素（IFN-γ）。肝外膜蛋白血清中主要的IgG2a抗体反应以及体外产生的IL-4或IL-5过量的IFN-γ与在感染幽门螺杆菌和幽门螺杆菌的人和小鼠中报道的Th1免疫反应一致。分别是幽门螺杆菌。感染了 H的小鼠。肝发展为由淋巴组织细胞和浆细胞浸润组成的严重的血管周围，门周围和肝实质病变。此外，在p.i的12个月时观察到透壁性肺炎。细胞介导的针对Th H的Th1免疫应答的表征。 A / JCr小鼠中的肝感染应被证明可作为实验方案的模型，该实验方案可操纵宿主对 Helicobacter 的反应。

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