Nonrestricted Differential Intoxication of Cells by Pertussis Toxin

Ali el Baya; Kerstin Brückener; M. Alexander Schmidt

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Nonrestricted Differential Intoxication of Cells by Pertussis Toxin

机译：百日咳毒素对细胞的非限制性差异性中毒

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After uptake and retrograde transport pertussis toxin acts by ADP-ribosylating α-G_i proteins. We show that uptake via many different receptor proteins followed by retrograde transport and intoxication is not restricted to a particular cell type. The efficiency of cellular intoxication, however, was found to be cell type dependent.

机译：摄取和逆行运输后，百日咳毒素通过ADP-核糖基化α-G_{i 蛋白起作用。我们表明，通过许多不同的受体蛋白摄取，然后逆行转运和中毒并不局限于特定的细胞类型。然而，发现细胞中毒的效率取决于细胞类型。}

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《Infection and immunity》 |1999年第1期|共3页
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Ali el Baya; Kerstin Brückener; M. Alexander Schmidt;
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中图分类医学免疫学;
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1. Newly secreted adenylate cyclase toxin is responsible for intoxication of target cells by Bordetella pertussis [J] . Gray MC, Donato GM, Jones FR, Molecular Microbiology . 2004,第6期

机译：新分泌的腺苷酸环化酶毒素引起百日咳博德特氏菌对靶细胞的中毒
2. Bordetella pertussis adenylate cyclase toxin: intoxication of host cells by bacterial invasion. [J] . M Mouallem, Z Farfel, E Hanski Infection and immunity . 1990,第11期

机译：百日咳博德特氏菌腺苷酸环化酶毒素：细菌入侵引起宿主细胞中毒。
3. Mutants of Escherichia coli Heat-Labile Toxin Act as Effective Mucosal Adjuvants for Nasal Delivery of an Acellular Pertussis Vaccine: Differential Effects of the Nontoxic AB Complex and Enzyme Activity on Th1 and Th2 Cells [J] . Elizabeth J. Ryan, Edel McNeela, Geraldine A. Murphy, Infection and immunity . 1999,第12期

机译：大肠杆菌热不稳定毒素突变体作为无黏膜百日咳疫苗经鼻递送的有效粘膜佐剂：无毒AB复合物和酶活性对Th1和Th2细胞的差异作用
4. Comprehensive Mass Spectrometric Analysis of Multiple Pertussis Toxins Reveals Amino Acid Homogeneity and Differential Subunit Expression [C] . Yulanda M. Williamson, Hercules Moura, David Schieltz, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：综合质谱分析多个百日咳毒素揭示氨基酸均匀性和差异亚基表达
5. Intoxication of phagocytic cells by the Pseudomonas aeruginosa toxin ExoU during acute pneumonia. [D] . Diaz, Maureen Helen. 2009

机译：急性肺炎期间铜绿假单胞菌毒素ExoU吞噬吞噬细胞。
6. Note: Nonrestricted Differential Intoxication of Cells by Pertussis Toxin [O] . Ali el Bayâ, Kerstin Brückener, M. Alexander Schmidt 1999

机译：注意：百日咳毒素对细胞的非限制性分化中毒
7. Mutants of Escherichia coli Heat-Labile Toxin Act as Effective Mucosal Adjuvants for Nasal Delivery of an Acellular Pertussis Vaccine: Differential Effects of the Nontoxic AB Complex and Enzyme Activity on Th1 and Th2 Cells [O] . Elizabeth J. Ryan, Edel McNeela, Geraldine A. Murphy, 1999

机译：大肠杆菌热不稳定毒素的突变体是一种用于鼻腔递送的有效粘膜佐剂，用于无细胞植物疫苗：无毒AB复合物和酶活性在Th1和Th2细胞上的差异效应
8. Elucidation of Pertussis Toxin-Sensitive Migration Signaling in Human Breast Cancer Cells. [R] . Rust, W. L. 2002

机译：对人乳腺癌细胞中百日咳毒素敏感迁移信号的阐明。

Nonrestricted Differential Intoxication of Cells by Pertussis Toxin

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