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首页> 外文期刊>Infection and immunity >Protective Immunity of Microsphere-Based Mucosal Vaccines against Lethal Intranasal Challenge withStreptococcus pneumoniae
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Protective Immunity of Microsphere-Based Mucosal Vaccines against Lethal Intranasal Challenge withStreptococcus pneumoniae

机译：基于微球的粘膜疫苗对肺炎链球菌致死性鼻内攻击的保护性免疫

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Mucosal vaccination of capsular polysaccharide (PS) ofStreptococcus pneumoniae and subsequent creation of the first line of immunological defense in mucosa were examined. Mucosal as well as systemic antibody responses to PS were evoked by peroral or intranasal immunization of BALB/c mice with PS-cholera toxin B subunit (CTB) conjugates entrapped in the alginate microspheres (AM). The bacterial colonization at the lung mucosa was most profoundly inhibited (<95%) by intranasal immunization with the naked conjugate (PS-CTB). The mice vaccinated orally with encapsulated conjugate [AM(PS-CTB)] showed significant reduction on the level of pneumococcal bacteremia (<99%). Eighty percent of the mice perorally immunized with AM (PS-CTB) were protected from lethal intranasal challenge with S. pneumoniae, whereas more than 60% of the mice in the other control groups died of infection. Our novel approach may prove to be important in the development of a mucosal vaccine that will provide protection of mucosal surfaces of host.
机译：检查了肺炎链球菌荚膜多糖（PS）的粘膜疫苗接种和粘膜免疫防御的第一线的建立。通过用包埋在藻酸盐微球体（AM）中的PS-霍乱毒素B亚基（CTB）结合物对BALB / c小鼠进行经口或鼻内免疫，可引起对PS的粘膜和全身抗体反应。裸结合物（PS-CTB）鼻内免疫可最大程度地抑制（<95％）肺粘膜细菌定植。口服包封的结合物[AM（PS-CTB）]接种的小鼠肺炎球菌菌血症水平显着降低（<99％）。经AM口服免疫（PS-CTB）的小鼠中有80％受到了 S的致死性鼻内攻击的保护。肺炎，而其他对照组中超过60％的小鼠死于感染。我们的新方法可能被证明对粘膜疫苗的开发很重要，该疫苗将为宿主的粘膜表面提供保护。

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