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首页> 外文期刊>Infection and immunity >Variation in the Bordetella pertussis Virulence Factors Pertussis Toxin and Pertactin in Vaccine Strains and Clinical Isolates in Finland
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Variation in the Bordetella pertussis Virulence Factors Pertussis Toxin and Pertactin in Vaccine Strains and Clinical Isolates in Finland

机译：芬兰疫苗株和临床分离株中百日咳博德特氏菌致病因子的百日咳毒素和百日咳杆菌粘附素的变化

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There is evidence that pertussis is reemerging in vaccinated populations. We have proposed, and provided evidence for, one explanation for this phenomenon in The Netherlands: antigenic divergence between vaccine strains and circulating strains. Finland has a pertussis vaccination history very similar to that of The Netherlands, and yet there is no evidence for an increase in the incidence of pertussis to the extent that it was observed in The Netherlands. A comparison of the Bordetella pertussisstrains circulating in the two countries may shed light on the differences in pertussis epidemiology. Here we investigated whether temporal changes had occurred in pertussis toxin and pertactin types produced by the Finnish B. pertussis population. We show that strains isolated before 1964 produced the same pertussis toxin and pertactin variants as the vaccine strains. However, these vaccine types were replaced in later years, and in the 1990s most strains were distinct from the vaccine strains with respect to the two proteins. These trends are similar to those found in the Dutch B. pertussis population. An interesting difference between the contemporary Finnish and Dutch B. pertussis populations was found in the frequencies of pertactin variants, possibly explaining the distinct epidemiology of pertussis in the two countries.
机译：有证据表明，百日咳在接种疫苗的人群中正在重新出现。我们已经为荷兰的这一现象提出了一种解释，并为之提供了证据：疫苗株与循环株之间的抗原差异。芬兰的百日咳疫苗接种历史与荷兰非常相似，但是没有证据表明百日咳的发病率会增加到荷兰观察到的程度。比较两国流通的百日咳博德特氏菌菌株，可能会揭示百日咳流行病学的差异。在这里，我们调查了芬兰 B产生的百日咳毒素和百日咳杆菌粘附素类型是否发生时间变化。百日咳人群。我们表明，1964年之前分离出的菌株产生的百日咳毒素和百日咳杆菌毒素变体与疫苗菌株相同。但是，这些疫苗类型在后来的几年中被替换，并且在1990年代，大多数菌株在两种蛋白质方面与疫苗菌株不同。这些趋势与荷兰 B中发现的趋势相似。百日咳人群。当代芬兰语与荷兰语 B之间的有趣区别。在百日咳杆菌粘附素变体的频率中发现了百日咳种群，这可能解释了两国百日咳的独特流行病学。

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